Literature DB >> 21315927

Designing drugs to avoid toxicity.

Graham F Smith1.   

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Year:  2011        PMID： 21315927     DOI： 10.1016/B978-0-12-381290-2.00001-X

Source DB:  PubMed          Journal:  Prog Med Chem        ISSN： 0079-6468


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  33 in total

1.  Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.

Authors:  Anthony V Pensa; Maris A Cinelli; Huiying Li; Georges Chreifi; Paramita Mukherjee; Linda J Roman; Pavel Martásek; Thomas L Poulos; Richard B Silverman
Journal:  J Med Chem       Date:  2017-08-04       Impact factor: 7.446

Review 2.  The influence of the 'organizational factor' on compound quality in drug discovery.

Authors:  Paul D Leeson; Stephen A St-Gallay
Journal:  Nat Rev Drug Discov       Date:  2011-09-30       Impact factor: 84.694

3.  Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore.

Authors:  Daniel E Beck; Monica Abdelmalak; Wei Lv; P V Narasimha Reddy; Gabrielle S Tender; Elizaveta O'Neill; Keli Agama; Christophe Marchand; Yves Pommier; Mark Cushman
Journal:  J Med Chem       Date:  2015-04-24       Impact factor: 7.446

4.  Inhibition of Myeloperoxidase.

Authors:  Jala Soubhye; Paul G Furtmüller; Francois Dufrasne; Christian Obinger
Journal:  Handb Exp Pharmacol       Date:  2021

5.  Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons.

Authors:  Daniel E Beck; Wei Lv; Monica Abdelmalak; Caroline B Plescia; Keli Agama; Christophe Marchand; Yves Pommier; Mark Cushman
Journal:  Bioorg Med Chem       Date:  2016-02-09       Impact factor: 3.641

6.  Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists.

Authors:  Miguel Guerrero; Mariangela Urbano; Jian Zhao; Melissa Crisp; Peter Chase; Peter Hodder; Marie-Therese Schaeffer; Steven Brown; Hugh Rosen; Edward Roberts
Journal:  Bioorg Med Chem Lett       Date:  2011-11-04       Impact factor: 2.823

7.  Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.

Authors:  Lori A Emert-Sedlak; H Marie Loughran; Haibin Shi; John L Kulp; Sherry T Shu; Jielu Zhao; Billy W Day; Jay E Wrobel; Allen B Reitz; Thomas E Smithgall
Journal:  Bioorg Med Chem Lett       Date:  2016-01-21       Impact factor: 2.823

8.  Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I.

Authors:  Mohamed S A Elsayed; Yafan Su; Ping Wang; Taresh Sethi; Keli Agama; Azhar Ravji; Christophe E Redon; Evgeny Kiselev; Katharine A Horzmann; Jennifer L Freeman; Yves Pommier; Mark Cushman
Journal:  J Med Chem       Date:  2017-06-28       Impact factor: 7.446

9.  Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354.

Authors:  Wandong Wen; Summer E Young; Matthew T Duvernay; Michael L Schulte; Kellie D Nance; Bruce J Melancon; Julie Engers; Charles W Locuson; Michael R Wood; J Scott Daniels; Wenjun Wu; Craig W Lindsley; Heidi E Hamm; Shaun R Stauffer
Journal:  Bioorg Med Chem Lett       Date:  2014-08-15       Impact factor: 2.823

10.  High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.

Authors:  Shanshan He; Prashi Jain; Billy Lin; Marc Ferrer; Zongyi Hu; Noel Southall; Xin Hu; Wei Zheng; Benjamin Neuenswander; Chul-Hee Cho; Yu Chen; Shilpa A Worlikar; Jeffrey Aubé; Richard C Larock; Frank J Schoenen; Juan J Marugan; T Jake Liang; Kevin J Frankowski
Journal:  ACS Comb Sci       Date:  2015-09-17       Impact factor: 3.784
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