| Literature DB >> 21315848 |
Zhenhua Yang1, Mariana Rosenthal, Noah A Rosenberg, Sarah Talarico, Lixin Zhang, Carl Marrs, Vibeke Østergaard Thomsen, Troels Lillebaek, Aase B Andersen.
Abstract
Mycobacterium tuberculosis may survive for decades in the human body in a state termed latent tuberculosis infection (LTBI). We investigated the occurrence during LTBI of insertion/deletion events in a selected set of mononucleotide simple sequence repeats, DNA sequence changes in four M. tuberculosis genes, and large sequence variations in 4750 M. tuberculosis open reading frames. We studied 13 paired M. tuberculosis clinical isolates, with each pair representing a reactivation of LTBI more than three decades after primary infection. Absence of sequence variations between paired isolates in nearly all investigated loci suggests a low likelihood of bacterial replication during LTBI.Entities:
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Year: 2011 PMID： 21315848 PMCID： PMC3104100 DOI： 10.1016/j.meegid.2011.02.002
Source DB: PubMed Journal: Infect Genet Evol ISSN： 1567-1348 Impact factor: 3.342