Literature DB >> 21315179

Fragment screening to predict druggability (ligandability) and lead discovery success.

Fredrik N B Edfeldt1, Rutger H A Folmer, Alexander L Breeze.   

Abstract

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Substances：

Year:  2011        PMID： 21315179     DOI： 10.1016/j.drudis.2011.02.002

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


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  54 in total

Review 1.  Finding the sweet spot: the role of nature and nurture in medicinal chemistry.

Authors:  Michael M Hann; György M Keserü
Journal:  Nat Rev Drug Discov       Date:  2012-04-30       Impact factor: 84.694

2.  2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.

Authors:  Véronique Hamon; Raphael Bourgeas; Pierre Ducrot; Isabelle Theret; Laura Xuereb; Marie Jeanne Basse; Jean Michel Brunel; Sebastien Combes; Xavier Morelli; Philippe Roche
Journal:  J R Soc Interface       Date:  2013-11-06       Impact factor: 4.118

Review 3.  An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challenge.

Authors:  Ugo Perricone; Maria Rita Gulotta; Jessica Lombino; Barbara Parrino; Stella Cascioferro; Patrizia Diana; Girolamo Cirrincione; Alessandro Padova
Journal:  Medchemcomm       Date:  2018-04-19       Impact factor: 3.597

Review 4.  Approaches to target tractability assessment - a practical perspective.

Authors:  Kristin K Brown; Michael M Hann; Ami S Lakdawala; Rita Santos; Pamela J Thomas; Kieran Todd
Journal:  Medchemcomm       Date:  2018-02-14       Impact factor: 3.597

5.  Elucidating the druggability of the human proteome with eFindSite.

Authors:  Omar Kana; Michal Brylinski
Journal:  J Comput Aided Mol Des       Date:  2019-03-19       Impact factor: 3.686

Review 6.  Mechanistic enzymology in drug discovery: a fresh perspective.

Authors:  Geoffrey A Holdgate; Thomas D Meek; Rachel L Grimley
Journal:  Nat Rev Drug Discov       Date:  2017-12-01       Impact factor: 84.694

7.  Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.

Authors:  Jorden A Johnson; Christos A Nicolaou; Steven E Kirberger; Anil K Pandey; Haitao Hu; William C K Pomerantz
Journal:  ACS Med Chem Lett       Date:  2019-11-22       Impact factor: 4.345

Review 8.  Targeting epigenetic protein-protein interactions with small-molecule inhibitors.

Authors:  Brian M Linhares; Jolanta Grembecka; Tomasz Cierpicki
Journal:  Future Med Chem       Date:  2020-06-19       Impact factor: 3.808

9.  Determination of ligand binding modes in weak protein-ligand complexes using sparse NMR data.

Authors:  Biswaranjan Mohanty; Martin L Williams; Bradley C Doak; Mansha Vazirani; Olga Ilyichova; Geqing Wang; Wolfgang Bermel; Jamie S Simpson; David K Chalmers; Glenn F King; Mehdi Mobli; Martin J Scanlon
Journal:  J Biomol NMR       Date:  2016-10-24       Impact factor: 2.835

Review 10.  Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions.

Authors:  Leah N Makley; Jason E Gestwicki
Journal:  Chem Biol Drug Des       Date:  2013-01       Impact factor: 2.817
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