Literature DB >> 21315147

High-resolution melting curve analysis to establish CYP2C19∗2 single nucleotide polymorphism: Comparison with hydrolysis SNP analysis.

Manna Temesvári1, József Paulik, László Kóbori, Katalin Monostory.   

Abstract

Clinically significant consequences of CYP2C19 polymorphism in drug metabolism require reliable genotyping methods for assaying large numbers of blood samples. Hydrolysis single nucleotide polymorphism analysis and high-resolution melting curve (HRM) analysis successfully genotyped the 114 liver donors for CYP2C19∗2. However, the HRM analysis was found to be more efficient, rapid, user- and cost-friendly method.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID: 21315147     DOI: 10.1016/j.mcp.2011.01.003

Source DB:  PubMed          Journal:  Mol Cell Probes        ISSN: 0890-8508            Impact factor:   2.365


  2 in total

1.  High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.

Authors:  Greyson P Twist; Roger Gaedigk; J Steven Leeder; Andrea Gaedigk
Journal:  Pharmacogenomics       Date:  2013-06       Impact factor: 2.533

2.  Development of a High-Resolution Melting Analysis Method for CYP2C19*17 Genotyping in Healthy Volunteers.

Authors:  Zahra Ghasemi; Mehrdad Hashemi; Mahsa Ejabati; Seyyed Meisam Ebrahimi; Hamidreza Kheiri Manjili; Ali Sharafi; Ali Ramazani
Journal:  Avicenna J Med Biotechnol       Date:  2016 Oct-Dec
  2 in total

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