Literature DB >> 21315067

Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma.

Minying Cai1, Zhonglin Liu, Hongchang Qu, Helen Fan, Zhiping Zheng, Victor J Hruby.   

Abstract

Peptides serve as effective drugs and contrast agents in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this we have been developing new methods to create 'tailor-made' peptides and peptide mimetics with improved pharmacological and physical properties. In this work we introduce novel peptide and small molecule conjugated molecules for earlier diagnosis and treatment of melanoma. Published by Elsevier B.V.

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Year:  2011        PMID: 21315067      PMCID: PMC3095766          DOI: 10.1016/j.ejphar.2011.01.032

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN: 0014-2999            Impact factor:   4.432


  28 in total

1.  alpha-Melanotropin: the minimal active sequence in the frog skin bioassay.

Authors:  V J Hruby; B C Wilkes; M E Hadley; F Al-Obeidi; T K Sawyer; D J Staples; A E de Vaux; O Dym; A M Castrucci; M F Hintz
Journal:  J Med Chem       Date:  1987-11       Impact factor: 7.446

2.  Control of melanogenesis in mouse melanoma cells of varying metastatic potential.

Authors:  R M Niles; J S Makarski
Journal:  J Natl Cancer Inst       Date:  1978-08       Impact factor: 13.506

3.  Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides.

Authors:  E Kaiser; R L Colescott; C D Bossinger; P I Cook
Journal:  Anal Biochem       Date:  1970-04       Impact factor: 3.365

4.  Conformational restrictions of biologically active peptides via amino acid side chain groups.

Authors:  V J Hruby
Journal:  Life Sci       Date:  1982-07-19       Impact factor: 5.037

5.  Synthesis and actions of a melanotropin conjugate, Ac-[Nle4, Glu(gamma-4'-hydroxyanilide)5, D-Phe7]alpha-MSH4-10-NH2, on melanocytes and melanoma cells in vitro.

Authors:  F al-Obeidi; M Mulcahy; V S Pitt; V Begay; M E Hadley; V J Hruby
Journal:  J Pharm Sci       Date:  1990-06       Impact factor: 3.534

6.  Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies.

Authors:  Lucas Doedens; Florian Opperer; Minying Cai; Johannes G Beck; Matt Dedek; Erin Palmer; Victor J Hruby; Horst Kessler
Journal:  J Am Chem Soc       Date:  2010-06-16       Impact factor: 15.419

7.  Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.

Authors:  F Al-Obeidi; A M Castrucci; M E Hadley; V J Hruby
Journal:  J Med Chem       Date:  1989-12       Impact factor: 7.446

8.  Use of an alpha-melanocyte-stimulating hormone analogue to improve alpha-melanocyte-stimulating hormone receptor binding assay in human melanoma.

Authors:  A Libert; G Ghanem; R Arnould; F J Lejeune
Journal:  Pigment Cell Res       Date:  1989 Nov-Dec

9.  Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity.

Authors:  M Cai; C Cai; A V Mayorov; C Xiong; C M Cabello; V A Soloshonok; J R Swift; D Trivedi; V J Hruby
Journal:  J Pept Res       Date:  2004-02

Review 10.  Macrophage imaging in central nervous system and in carotid atherosclerotic plaque using ultrasmall superparamagnetic iron oxide in magnetic resonance imaging.

Authors:  Claire Corot; Klaus G Petry; Rikin Trivedi; Andreas Saleh; Cornelia Jonkmanns; Jean-François Le Bas; Erwin Blezer; Martin Rausch; Bruno Brochet; Paula Foster-Gareau; Danièle Balériaux; Sophile Gaillard; Vincent Dousset
Journal:  Invest Radiol       Date:  2004-10       Impact factor: 6.016

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  2 in total

Review 1.  The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases.

Authors:  Minying Cai; Victor J Hruby
Journal:  Curr Protein Pept Sci       Date:  2016       Impact factor: 3.272

Review 2.  Novel approaches to the design of bioavailable melanotropins.

Authors:  Yang Zhou; Minying Cai
Journal:  Expert Opin Drug Discov       Date:  2017-07-12       Impact factor: 6.098

  2 in total

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