UNLABELLED: Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. PURPOSE: To examine the role of MSK1/2 in skin tumor development. RESULTS: MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1β as well as the mRNA expression of TNF-α were significantly increased in MSK1/2 knockout mice. CONCLUSION: These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.
UNLABELLED: Mitogen- and stress-activated protein kinase (MSK)1/2 are two kinases involved in inflammation as well as in cell transformation. PURPOSE: To examine the role of MSK1/2 in skin tumor development. RESULTS:MSK1/2 knockout mice developed significantly fewer skin tumors compared with wild-type mice. The myeloperoxidase activity in TPA-treated skin from MSK1/2 knockout mice was significantly elevated compared with wild-type mice. Furthermore, the mRNA and protein levels of IL-1β as well as the mRNA expression of TNF-α were significantly increased in MSK1/2 knockout mice. CONCLUSION: These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis.
Authors: Ke Yao; Hanyong Chen; Kangdong Liu; Alyssa Langfald; Ge Yang; Yi Zhang; Dong Hoon Yu; Myoung Ok Kim; Mee-Hyun Lee; Haitao Li; Ki Beom Bae; Hong-Gyum Kim; Wei-Ya Ma; Ann M Bode; Ziming Dong; Zigang Dong Journal: Cancer Prev Res (Phila) Date: 2014-07-03
Authors: Haidan Liu; Joonsung Hwang; Wei Li; Tae Woong Choi; Kangdong Liu; Zunnan Huang; Jae-Hyuk Jang; N R Thimmegowda; Ki Won Lee; In-Ja Ryoo; Jong-Seog Ahn; Ann M Bode; Xinmin Zhou; Yifeng Yang; Raymond L Erikson; Bo-Yeon Kim; Zigang Dong Journal: Cancer Prev Res (Phila) Date: 2013-10-29
Authors: Shawn S Badal; Yin Wang; Jianyin Long; David L Corcoran; Benny H Chang; Luan D Truong; Yashpal S Kanwar; Paul A Overbeek; Farhad R Danesh Journal: Nat Commun Date: 2016-06-28 Impact factor: 14.919