OBJECTIVE: The aim of this study was to test whether a functional polymorphism (-174C/G) located in the promoter region of the interleukin-6 (IL-6) gene is associated with primary short-term outcome (death or Intensive Care Unit discharge) in patients with severe traumatic brain injury (TBI). METHODS: The study group consisted of 77 male patients who suffered severe TBI. The -174C/G IL-6 polymorphism was analysed by polymerase chain reaction (PCR) followed by restriction digestion. RESULTS: Severe TBI was associated with a 44% mortality rate. The GG genotype was significantly more frequent in the survivor group than in non-surviving patients (67% vs 41%; p =?0.038); similarly, the IL-6 -174G allele was more frequent in the survivor group than in non-surviving patients (81% vs 65%; p =0.031). CONCLUSION: The findings indicate that genetic variation regarding inflammatory response has significant impact on the short-term outcome for patients after acute severe TBI.
OBJECTIVE: The aim of this study was to test whether a functional polymorphism (-174C/G) located in the promoter region of the interleukin-6 (IL-6) gene is associated with primary short-term outcome (death or Intensive Care Unit discharge) in patients with severe traumatic brain injury (TBI). METHODS: The study group consisted of 77 male patients who suffered severe TBI. The -174C/GIL-6 polymorphism was analysed by polymerase chain reaction (PCR) followed by restriction digestion. RESULTS: Severe TBI was associated with a 44% mortality rate. The GG genotype was significantly more frequent in the survivor group than in non-surviving patients (67% vs 41%; p =?0.038); similarly, the IL-6 -174G allele was more frequent in the survivor group than in non-surviving patients (81% vs 65%; p =0.031). CONCLUSION: The findings indicate that genetic variation regarding inflammatory response has significant impact on the short-term outcome for patients after acute severe TBI.
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Authors: Carrie Esopenko; Jessica Meyer; Elisabeth A Wilde; Amy D Marshall; David F Tate; Alexander P Lin; Inga K Koerte; Kimberly B Werner; Emily L Dennis; Ashley L Ware; Nicola L de Souza; Deleene S Menefee; Kristen Dams-O'Connor; Dan J Stein; Erin D Bigler; Martha E Shenton; Kathy S Chiou; Judy L Postmus; Kathleen Monahan; Brenda Eagan-Johnson; Paul van Donkelaar; Tricia L Merkley; Carmen Velez; Cooper B Hodges; Hannah M Lindsey; Paula Johnson; Andrei Irimia; Matthew Spruiell; Esther R Bennett; Ashley Bridwell; Glynnis Zieman; Frank G Hillary Journal: Brain Imaging Behav Date: 2021-01-06 Impact factor: 3.978