Literature DB >> 21314234

Novel IkB kinase inhibitors for treatment of nuclear factor-kB-related diseases.

Jun-ichi Suzuki1, Masahito Ogawa, Susumu Muto, Akiko Itai, Mitsuaki Isobe, Yasunobu Hirata, Ryozo Nagai.   

Abstract

INTRODUCTION: NF-kB is a key regulator of inflammation and immunity in cancer development. The IkB kinase (IKK) is a multisubunit complex containing catalytic subunits termed IKK-α, -β and -γ. It is well known that many pro-inflammatory stimuli require the IKK-β subunit for NF-kB activation. AREAS COVERED: NF-kB affects the progression of inflammation-related diseases,such as myocardial ischemia, bronchial asthma, arthritis, cancer and other diseases. We review the characteristics and effects of these inhibitors on inflammatory and other diseases. EXPERT OPINION: Various synthesized IKK inhibitors have been developed and they will be used clinically in the near future.

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Year:  2011        PMID： 21314234     DOI： 10.1517/13543784.2011.559162

Source DB:  PubMed          Journal:  Expert Opin Investig Drugs        ISSN： 1354-3784            Impact factor:   6.206


  26 in total

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Authors:  Jeffrey L Ebersole; Michael John Novak; Luis Orraca; Janis Martinez-Gonzalez; Sreenatha Kirakodu; Kuey C Chen; Arnold Stromberg; Octavio A Gonzalez
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