| Literature DB >> 21310720 |
P Dewachter1, S Castro, P Nicaise-Roland, S Chollet-Martin, C Le Beller, A Lillo-le-Louet, C Mouton-Faivre.
Abstract
Methylene blue-treated fresh-frozen plasma (MB-FFP) is mainly used in Europe. The advantage of the methylene blue system is that units can be treated individually. The combined action of methylene blue and illumination is a photodynamic process preventing viral RNA and DNA replication. We report the first immediate allergic hypersensitivity reaction to methylene blue-treated plasma transfusion. The clinical course and subsequent assessment of the allergic reaction, including skin tests and basophil activation test, confirmed methylene blue-induced IgE-mediated anaphylaxis. All immediate reactions after MB-FFP transfusion should be investigated to document the underlying mechanism.Entities:
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Year: 2011 PMID: 21310720 DOI: 10.1093/bja/aer009
Source DB: PubMed Journal: Br J Anaesth ISSN: 0007-0912 Impact factor: 9.166