Literature DB >> 21310705

Telomeres: unlocking the mystery of cell division and aging.

Guido R Zanni1, Jeannette Y Wick.   

Abstract

Telomeres are DNA sequences that cap the ends of chromosomes, protecting them from fraying and fusing together during replication. During replication, telomeres lose some of their genetic material but are repaired by the ribonucleoprotein telomerase. Both telomeres and telomerase are linked to cell senescence and apoptosis, and research suggests they play key roles in aging, cancer, hereditary syndromes, and chronic diseases. Several theories of aging are reviewed along with the potential impact of telomerase in developing new treatments.

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Year:  2011        PMID： 21310705     DOI： 10.4140/TCP.n.2011.78

Source DB:  PubMed          Journal:  Consult Pharm        ISSN： 0888-5109


  5 in total

Review 1.  An integrative review of factors associated with telomere length and implications for biobehavioral research.

Authors:  Angela R Starkweather; Areej A Alhaeeri; Alison Montpetit; Jenni Brumelle; Kristin Filler; Marty Montpetit; Lathika Mohanraj; Debra E Lyon; Colleen K Jackson-Cook
Journal:  Nurs Res       Date:  2014 Jan-Feb       Impact factor: 2.381

2.  A biobehavioral perspective on telomere length and the exposome.

Authors:  Debra E Lyon; Angela R Starkweather; Alison Montpetit; Victoria Menzies; Nancy Jallo
Journal:  Biol Res Nurs       Date:  2014-03-04       Impact factor: 2.522

Review 3.  Meditation as a therapeutic intervention for adults at risk for Alzheimer's disease - potential benefits and underlying mechanisms.

Authors:  Kim E Innes; Terry Kit Selfe
Journal:  Front Psychiatry       Date:  2014-04-23       Impact factor: 4.157

4.  PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration.

Authors:  Shengguang Wang; Hua Zhang; Jianquan Zhu; Chenguang Li; Jinfang Zhu; Bowen Shi; Bin Zhang; Changli Wang
Journal:  Biomed Res Int       Date:  2017-07-26       Impact factor: 3.411

5.  Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres.

Authors:  L Martinsson; Y Wei; D Xu; P A Melas; A A Mathé; M Schalling; C Lavebratt; L Backlund
Journal:  Transl Psychiatry       Date:  2013-05-21       Impact factor: 6.222
  5 in total

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