Literature DB >> 21310483

DIGE-based proteomic analysis identifies nucleophosmin/B23 and nucleolin C23 as over-expressed proteins in relapsed/refractory acute leukemia.

Jianda Hu1, Minhui Lin, Tingbo Liu, Jing Li, Buyuan Chen, Yingyu Chen.   

Abstract

Drug resistance is a challenge in treatment of acute leukemia. To investigate novel protein changes involved in resistance, protein expression profiles between leukemia cell line HL-60 and adriamycin-resistant HL-60 (HL-60/ADR) were compared based on a proteomic approach-2D-DIGE followed by MALDI-TOF/MS. 13 protein spots were identified as up-regulated and 3 down-regulated in HL-60/ADR. Nucleophosmin/B23 (NPM B23) and nucleolin C23 (C23) were selected and verified by western blot, which showed an obvious up-regulation in leukemia cells, especially in 3 resistant leukemia cell lines and in relapsed/refractory patients. To a conclusion, B23 and C23 may be involved in drug resistance and be useful in assessing the prognosis of leukemia.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21310483     DOI： 10.1016/j.leukres.2011.01.010

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  8 in total

1.  Nucleophosmin1 associated with drug resistance and recurrence of bladder cancer.

Authors:  Huihui Hu; Qian Meng; Ting Lei; Man Zhang
Journal:  Clin Exp Med       Date:  2014-06-13       Impact factor: 3.984

2.  C23 protein meditates bone morphogenetic protein-2-mediated EMT via up-regulation of Erk1/2 and Akt in gastric cancer.

Authors:  Yonggang Yang; Chunyan Yang; Jianping Zhang
Journal:  Med Oncol       Date:  2015-02-20       Impact factor: 3.064

3.  Inhibition of 32Dp210 cells harboring T315I mutation by a novel derivative of emodin correlates with down-regulation of BCR-ABL and its downstream signaling pathways.

Authors:  Jing Li; Yingyu Chen; Buyuan Chen; Cai Chen; Binglin Qiu; Zhihong Zheng; Jing Zheng; Tingbo Liu; Wenfeng Wang; Jianda Hu
Journal:  J Cancer Res Clin Oncol       Date:  2014-09-14       Impact factor: 4.553

4.  Identification of proteins differentially expressed in adriamycin-resistant (pumc-91/ADM) and parental (pumc-91) human bladder cancer cell lines by proteome analysis.

Authors:  Qian Meng; Ting Lei; Min Zhang; Jin Zhao; Xu-Hong Zhao; Man Zhang
Journal:  J Cancer Res Clin Oncol       Date:  2012-11-27       Impact factor: 4.553

5.  Effect of nucleolin on adriamycin resistance via the regulation of B-cell lymphoma 2 expression in Burkitt's lymphoma cells.

Authors:  Xuqiao Mei; Yanxin Chen; Donghui Gan; Yingyu Chen; Lingyan Wang; Yanqin Cao; Zhengjun Wu; Weijuan Liu; Chenxing Zhao; Minhui Lin; Ting Yang; Jianda Hu
Journal:  J Cell Physiol       Date:  2019-05-24       Impact factor: 6.384

Review 6.  Proteomics-based discovery of biomarkers for paediatric acute lymphoblastic leukaemia: challenges and opportunities.

Authors:  Elena López Villar; Duojiao Wu; William C Cho; Luis Madero; Xiangdong Wang
Journal:  J Cell Mol Med       Date:  2014-06-09       Impact factor: 5.310

7.  E35 ablates acute leukemia stem and progenitor cells in vitro and in vivo.

Authors:  Yingyu Chen; Jing Zheng; Donghui Gan; Yanxin Chen; Na Zhang; Yuwen Chen; Zhenxing Lin; Wenfeng Wang; Haijun Chen; Donghong Lin; Jianda Hu
Journal:  J Cell Physiol       Date:  2020-01-21       Impact factor: 6.384

Review 8.  Application of High Throughput Technologies in the Development of Acute Myeloid Leukemia Therapy: Challenges and Progress.

Authors:  Wei Xiang; Yi Hui Lam; Giridharan Periyasamy; Charles Chuah
Journal:  Int J Mol Sci       Date:  2022-03-05       Impact factor: 5.923
  8 in total

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