| Literature DB >> 21309613 |
Weidong Zhou1, Michela Capello, Claudia Fredolini, Lorenzo Piemonti, Lance A Liotta, Francesco Novelli, Emanuel F Petricoin.
Abstract
In this present work, we characterized the proteomes of pancreatic ductal adenocarcinoma (PDAC) cells and normal pancreatic duct cells by mass spectrometry using LTQ-Orbitrap, and identified more than 1200 proteins from each sample. On the basis of spectra count label-free quantification approach, we identified a large number of differentially expressed metabolic enzymes and proteins involved in cytoskeleton, cell adhesion, transport, transcription, translation, and cell proliferation as well. The data demonstrated that metabolic pathways were altered in PDAC, consistent with Warburg effect. Our analysis provides a potentially comprehensive picture of metabolism in PDAC, which may serve as the basis of new diagnostic and treatment of PDAC.Entities:
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Year: 2011 PMID： 21309613 DOI： 10.1021/pr101179t
Source DB: PubMed Journal: J Proteome Res ISSN： 1535-3893 Impact factor: 4.466