| Literature DB >> 21309590 |
André J Zaharenko1, Gisele Picolo, Wilson A Ferreira, Takanori Murakami, Kohei Kazuma, Masaru Hashimoto, Yara Cury, José C de Freitas, Motoyoshi Satake, Katsuhiro Konno.
Abstract
A new acylamino acid, bunodosine 391 (BDS 391), was isolated from the venom of the sea anemone Bunodosoma cangicum. The structure was elucidated by spectroscopic analyses (2D NMR, ESIMS/MS) and verified by its synthesis. Intraplantar injection of BDS 391 into the hind paw of a rat induced a potent analgesic effect. This effect was not altered by naloxone (an opioid receptor antagonist), but was completely reversed by methysergide (a serotonin receptor antagonist), indicating that the effect is mediated by activation of serotonin receptors.Entities:
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Year: 2011 PMID： 21309590 DOI： 10.1021/np100738m
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050