| Literature DB >> 21309528 |
Matthew Brichacek1, Mauricio Navarro Villalobos, Alexandra Plichta, Jon T Njardarson.
Abstract
In this report, it is demonstrated that chiral vinyl aziridines can be stereospecifically ring expanded. This synthetic approach allows controlled access to chiral 2,5-cis- or 2,5-trans-3-pyrroline products from starting materials with the appropriate aziridine geometry. Twenty three ring expansion examples, most of which feature a stereospecific cyclization, are presented.Entities:
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Year: 2011 PMID： 21309528 PMCID： PMC3072884 DOI： 10.1021/ol200263g
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005