OBJECTIVE: To determine whether the thymus is smaller in fetuses of pre-eclamptic mothers than in those of normal controls. METHODS: This was a cross-sectional, prospective, comparative study of sonographically determined fetal thymus measurements in 39 pregnancies with pre-eclampsia and 70 healthy pregnancies. RESULTS: Both the diameter and the perimeter of the fetal thymus were smaller in pregnancies with pre-eclampsia than in healthy controls. The means of the thymus diameters were 28.6 ± 5.9 and 32.9 ± 4.5 mm and of thymus perimeters 80.9 ± 16.5 and 93.1 ± 16.6 mm for pre-eclamptic and healthy pregnancies, respectively (P < 0.001). General linear models showed that smaller fetal thymuses in pre-eclampsia were independent of gestational age, estimated fetal weight, small for gestational age status and antenatal steroid use. CONCLUSIONS: Pre-eclampsia is associated with smaller fetal thymuses.
OBJECTIVE: To determine whether the thymus is smaller in fetuses of pre-eclamptic mothers than in those of normal controls. METHODS: This was a cross-sectional, prospective, comparative study of sonographically determined fetal thymus measurements in 39 pregnancies with pre-eclampsia and 70 healthy pregnancies. RESULTS: Both the diameter and the perimeter of the fetal thymus were smaller in pregnancies with pre-eclampsia than in healthy controls. The means of the thymus diameters were 28.6 ± 5.9 and 32.9 ± 4.5 mm and of thymus perimeters 80.9 ± 16.5 and 93.1 ± 16.6 mm for pre-eclamptic and healthy pregnancies, respectively (P < 0.001). General linear models showed that smaller fetal thymuses in pre-eclampsia were independent of gestational age, estimated fetal weight, small for gestational age status and antenatal steroid use. CONCLUSIONS: Pre-eclampsia is associated with smaller fetal thymuses.
Authors: Daniel Munblit; Diego G Peroni; Alba Boix-Amorós; Peter S Hsu; Belinda Van't Land; Melvin C L Gay; Anastasia Kolotilina; Chrysanthi Skevaki; Robert J Boyle; Maria Carmen Collado; Johan Garssen; Donna T Geddes; Ralph Nanan; Carolyn Slupsky; Ganesa Wegienka; Anita L Kozyrskyj; John O Warner Journal: Nutrients Date: 2017-08-17 Impact factor: 5.717
Authors: Katarzyna Zych-Krekora; Michał Krekora; Maciej Słodki; Mariusz Grzesiak; Piotr Kaczmarek; Krzysztof Zeman; Maria Respondek-Liberska Journal: Arch Med Sci Date: 2019-07-11 Impact factor: 3.318