| Literature DB >> 213081 |
G Schlierf, P Oster, C C Heuck, H Raetzer, B Schellenberg.
Abstract
The effect of beta-sitosterol on plasma lipids and lipoproteins was evaluated in a randomized double-blind cross-over trial in 15 children and adolescents with familial hypercholesterolemia over a period of 6 months. Twelve patients completed the study, with good adherence to drug intake. Sitosterol lowered the plasma total choelsterol by 6%, LDL cholesterol by 7% and HDL cholesterol by 15% (P less than 0.05). This insufficient response of total and LDL cholesterol and the marked fall of HDL cholesterol appears to advise against the use of beta-sitosterol granulate in juvenile type II hyperlipoproteinemia.Entities:
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Year: 1978 PMID： 213081 DOI： 10.1016/0021-9150(78)90116-8
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162