Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Initial impact of the sequencing of the human genome.

Literature DB >> 21307931

Initial impact of the sequencing of the human genome.

Abstract

The sequence of the human genome has dramatically accelerated biomedical research. Here I explore its impact, in the decade since its publication, on our understanding of the biological functions encoded in the genome, on the biological basis of inherited diseases and cancer, and on the evolution and history of the human species. I also discuss the road ahead in fulfilling the promise of genomics for medicine.

Entities: Disease Species

Mesh：

Year: 2011 PMID： 21307931 DOI： 10.1038/nature09792

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

95 in total

1. Detection of regulatory variation in mouse genes.

Authors: Christopher R Cowles; Joel N Hirschhorn; David Altshuler; Eric S Lander
Journal: Nat Genet Date: 2002-10-15 Impact factor: 38.330

2. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.

Authors: Nathaniel D Heintzman; Rhona K Stuart; Gary Hon; Yutao Fu; Christina W Ching; R David Hawkins; Leah O Barrera; Sara Van Calcar; Chunxu Qu; Keith A Ching; Wei Wang; Zhiping Weng; Roland D Green; Gregory E Crawford; Bing Ren
Journal: Nat Genet Date: 2007-02-04 Impact factor: 38.330

3. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

Authors: Siân Jones; Tian-Li Wang; Ie-Ming Shih; Tsui-Lien Mao; Kentaro Nakayama; Richard Roden; Ruth Glas; Dennis Slamon; Luis A Diaz; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu; Nickolas Papadopoulos
Journal: Science Date: 2010-09-08 Impact factor: 47.728

4. DNMT3A mutations in acute myeloid leukemia.

Authors: Timothy J Ley; Li Ding; Matthew J Walter; Michael D McLellan; Tamara Lamprecht; David E Larson; Cyriac Kandoth; Jacqueline E Payton; Jack Baty; John Welch; Christopher C Harris; Cheryl F Lichti; R Reid Townsend; Robert S Fulton; David J Dooling; Daniel C Koboldt; Heather Schmidt; Qunyuan Zhang; John R Osborne; Ling Lin; Michelle O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Vincent J Magrini; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Joshua J Conyers; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd Wylie; Jason Walker; Joelle Kalicki; Mark A Watson; Sharon Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Peter Westervelt; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Richard K Wilson
Journal: N Engl J Med Date: 2010-11-10 Impact factor: 91.245

5. Rare chromosomal deletions and duplications increase risk of schizophrenia.

Authors:
Journal: Nature Date: 2008-07-30 Impact factor: 49.962

6. Strong association of de novo copy number mutations with autism.

Authors: Jonathan Sebat; B Lakshmi; Dheeraj Malhotra; Jennifer Troge; Christa Lese-Martin; Tom Walsh; Boris Yamrom; Seungtai Yoon; Alex Krasnitz; Jude Kendall; Anthony Leotta; Deepa Pai; Ray Zhang; Yoon-Ha Lee; James Hicks; Sarah J Spence; Annette T Lee; Kaija Puura; Terho Lehtimäki; David Ledbetter; Peter K Gregersen; Joel Bregman; James S Sutcliffe; Vaidehi Jobanputra; Wendy Chung; Dorothy Warburton; Mary-Claire King; David Skuse; Daniel H Geschwind; T Conrad Gilliam; Kenny Ye; Michael Wigler
Journal: Science Date: 2007-03-15 Impact factor: 47.728

7. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.

Authors: Tarjei S Mikkelsen; Matthew J Wakefield; Bronwen Aken; Chris T Amemiya; Jean L Chang; Shannon Duke; Manuel Garber; Andrew J Gentles; Leo Goodstadt; Andreas Heger; Jerzy Jurka; Michael Kamal; Evan Mauceli; Stephen M J Searle; Ted Sharpe; Michelle L Baker; Mark A Batzer; Panayiotis V Benos; Katherine Belov; Michele Clamp; April Cook; James Cuff; Radhika Das; Lance Davidow; Janine E Deakin; Melissa J Fazzari; Jacob L Glass; Manfred Grabherr; John M Greally; Wanjun Gu; Timothy A Hore; Gavin A Huttley; Michael Kleber; Randy L Jirtle; Edda Koina; Jeannie T Lee; Shaun Mahony; Marco A Marra; Robert D Miller; Robert D Nicholls; Mayumi Oda; Anthony T Papenfuss; Zuly E Parra; David D Pollock; David A Ray; Jacqueline E Schein; Terence P Speed; Katherine Thompson; John L VandeBerg; Claire M Wade; Jerilyn A Walker; Paul D Waters; Caleb Webber; Jennifer R Weidman; Xiaohui Xie; Michael C Zody; Jennifer A Marshall Graves; Chris P Ponting; Matthew Breen; Paul B Samollow; Eric S Lander; Kerstin Lindblad-Toh
Journal: Nature Date: 2007-05-10 Impact factor: 49.962

8. The transcriptional landscape of the mammalian genome.

Authors: P Carninci; T Kasukawa; S Katayama; J Gough; M C Frith; N Maeda; R Oyama; T Ravasi; B Lenhard; C Wells; R Kodzius; K Shimokawa; V B Bajic; S E Brenner; S Batalov; A R R Forrest; M Zavolan; M J Davis; L G Wilming; V Aidinis; J E Allen; A Ambesi-Impiombato; R Apweiler; R N Aturaliya; T L Bailey; M Bansal; L Baxter; K W Beisel; T Bersano; H Bono; A M Chalk; K P Chiu; V Choudhary; A Christoffels; D R Clutterbuck; M L Crowe; E Dalla; B P Dalrymple; B de Bono; G Della Gatta; D di Bernardo; T Down; P Engstrom; M Fagiolini; G Faulkner; C F Fletcher; T Fukushima; M Furuno; S Futaki; M Gariboldi; P Georgii-Hemming; T R Gingeras; T Gojobori; R E Green; S Gustincich; M Harbers; Y Hayashi; T K Hensch; N Hirokawa; D Hill; L Huminiecki; M Iacono; K Ikeo; A Iwama; T Ishikawa; M Jakt; A Kanapin; M Katoh; Y Kawasawa; J Kelso; H Kitamura; H Kitano; G Kollias; S P T Krishnan; A Kruger; S K Kummerfeld; I V Kurochkin; L F Lareau; D Lazarevic; L Lipovich; J Liu; S Liuni; S McWilliam; M Madan Babu; M Madera; L Marchionni; H Matsuda; S Matsuzawa; H Miki; F Mignone; S Miyake; K Morris; S Mottagui-Tabar; N Mulder; N Nakano; H Nakauchi; P Ng; R Nilsson; S Nishiguchi; S Nishikawa; F Nori; O Ohara; Y Okazaki; V Orlando; K C Pang; W J Pavan; G Pavesi; G Pesole; N Petrovsky; S Piazza; J Reed; J F Reid; B Z Ring; M Ringwald; B Rost; Y Ruan; S L Salzberg; A Sandelin; C Schneider; C Schönbach; K Sekiguchi; C A M Semple; S Seno; L Sessa; Y Sheng; Y Shibata; H Shimada; K Shimada; D Silva; B Sinclair; S Sperling; E Stupka; K Sugiura; R Sultana; Y Takenaka; K Taki; K Tammoja; S L Tan; S Tang; M S Taylor; J Tegner; S A Teichmann; H R Ueda; E van Nimwegen; R Verardo; C L Wei; K Yagi; H Yamanishi; E Zabarovsky; S Zhu; A Zimmer; W Hide; C Bult; S M Grimmond; R D Teasdale; E T Liu; V Brusic; J Quackenbush; C Wahlestedt; J S Mattick; D A Hume; C Kai; D Sasaki; Y Tomaru; S Fukuda; M Kanamori-Katayama; M Suzuki; J Aoki; T Arakawa; J Iida; K Imamura; M Itoh; T Kato; H Kawaji; N Kawagashira; T Kawashima; M Kojima; S Kondo; H Konno; K Nakano; N Ninomiya; T Nishio; M Okada; C Plessy; K Shibata; T Shiraki; S Suzuki; M Tagami; K Waki; A Watahiki; Y Okamura-Oho; H Suzuki; J Kawai; Y Hayashizaki
Journal: Science Date: 2005-09-02 Impact factor: 47.728

9. A method for high-throughput gene expression signature analysis.

Authors: David Peck; Emily D Crawford; Kenneth N Ross; Kimberly Stegmaier; Todd R Golub; Justin Lamb
Journal: Genome Biol Date: 2006 Impact factor: 13.583

10. Large recurrent microdeletions associated with schizophrenia.

Authors: Hreinn Stefansson; Dan Rujescu; Sven Cichon; Olli P H Pietiläinen; Andres Ingason; Stacy Steinberg; Ragnheidur Fossdal; Engilbert Sigurdsson; Thordur Sigmundsson; Jacobine E Buizer-Voskamp; Thomas Hansen; Klaus D Jakobsen; Pierandrea Muglia; Clyde Francks; Paul M Matthews; Arnaldur Gylfason; Bjarni V Halldorsson; Daniel Gudbjartsson; Thorgeir E Thorgeirsson; Asgeir Sigurdsson; Adalbjorg Jonasdottir; Aslaug Jonasdottir; Asgeir Bjornsson; Sigurborg Mattiasdottir; Thorarinn Blondal; Magnus Haraldsson; Brynja B Magnusdottir; Ina Giegling; Hans-Jürgen Möller; Annette Hartmann; Kevin V Shianna; Dongliang Ge; Anna C Need; Caroline Crombie; Gillian Fraser; Nicholas Walker; Jouko Lonnqvist; Jaana Suvisaari; Annamarie Tuulio-Henriksson; Tiina Paunio; Timi Toulopoulou; Elvira Bramon; Marta Di Forti; Robin Murray; Mirella Ruggeri; Evangelos Vassos; Sarah Tosato; Muriel Walshe; Tao Li; Catalina Vasilescu; Thomas W Mühleisen; August G Wang; Henrik Ullum; Srdjan Djurovic; Ingrid Melle; Jes Olesen; Lambertus A Kiemeney; Barbara Franke; Chiara Sabatti; Nelson B Freimer; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Ole A Andreassen; Roel A Ophoff; Alexander Georgi; Marcella Rietschel; Thomas Werge; Hannes Petursson; David B Goldstein; Markus M Nöthen; Leena Peltonen; David A Collier; David St Clair; Kari Stefansson
Journal: Nature Date: 2008-09-11 Impact factor: 49.962

349 in total

Review 1. Understanding the genetics of coronary artery disease through the lens of noninvasive imaging.

Authors: Eunice Yang; Jose D Vargas; David A Bluemke
Journal: Expert Rev Cardiovasc Ther Date: 2012-01

2. Next generation analytic tools for large scale genetic epidemiology studies of complex diseases.

Authors: Leah E Mechanic; Huann-Sheng Chen; Christopher I Amos; Nilanjan Chatterjee; Nancy J Cox; Rao L Divi; Ruzong Fan; Emily L Harris; Kevin Jacobs; Peter Kraft; Suzanne M Leal; Kimberly McAllister; Jason H Moore; Dina N Paltoo; Michael A Province; Erin M Ramos; Marylyn D Ritchie; Kathryn Roeder; Daniel J Schaid; Matthew Stephens; Duncan C Thomas; Clarice R Weinberg; John S Witte; Shunpu Zhang; Sebastian Zöllner; Eric J Feuer; Elizabeth M Gillanders
Journal: Genet Epidemiol Date: 2011-12-06 Impact factor: 2.135

Review 3. Clinical implementation of comprehensive strategies to characterize cancer genomes: opportunities and challenges.

Authors: Laura E MacConaill; Paul Van Hummelen; Matthew Meyerson; William C Hahn
Journal: Cancer Discov Date: 2011-09 Impact factor: 39.397

Initial impact of the sequencing of the human genome.

1. Detection of regulatory variation in mouse genes.

2. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome.

3. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

4. DNMT3A mutations in acute myeloid leukemia.

5. Rare chromosomal deletions and duplications increase risk of schizophrenia.

6. Strong association of de novo copy number mutations with autism.

7. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.

8. The transcriptional landscape of the mammalian genome.

9. A method for high-throughput gene expression signature analysis.

10. Large recurrent microdeletions associated with schizophrenia.

Review 1. Understanding the genetics of coronary artery disease through the lens of noninvasive imaging.

2. Next generation analytic tools for large scale genetic epidemiology studies of complex diseases.

Review 3. Clinical implementation of comprehensive strategies to characterize cancer genomes: opportunities and challenges.

4. Federal politics and the clinical and translational sciences.

5. The mystery of missing heritability: Genetic interactions create phantom heritability.

6. Communication about DTC testing: commentary on a 'family experience of personal genomics'.

7. A role for fibrocytes in peritoneal fibrosis?

8. Uncovering the role of genomic "dark matter" in human disease.

Review 9. Translational regulation in nutrigenomics.

Review 10. Age-related macular degeneration: genetics and biology coming together.