| Literature DB >> 21307212 |
Sheila de Oliveira Garcia1, Walter Kleine Neto, Antonio Charlys da Costa, Sabri Saeed Sanabani, Alfredo Mendrone, Juliana Pereira, Ester Cerdeira Sabino.
Abstract
The molecular prevalence of human parvovirus B19V (B19V) in bone marrow (BM) samples from 120 cases with cytopenias of unknown etiology was compared with that in samples from 45 BM donors (control group 1) and 120 oncohematological patients (control group 2) to determine the role that B19V genotypes may play in unexplained cytopenias. Of the 285 participants, the BM samples of 39 (13.7%) contained B19V DNA (21 with genotype 1, 5 with genotype 2, and 13 with genotype 3). The prevalences of B19V were similar between case and control subjects (15.0% versus 12.7%, respectively). Genotypes 2 and 3 were associated with older age and were detected in similar proportions between case and control group 2 subjects. The results of this study do not support a role for B19V genotype variants in the etiology of unexplained cytopenias.Entities:
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Year: 2011 PMID： 21307212 PMCID： PMC3122794 DOI： 10.1128/JCM.00077-11
Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948