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Literature DB >> 21307091

A landmark-free morphometric staging system for the mouse limb bud.

Bernd Boehm¹, Michael Rautschka, Laura Quintana, Jelena Raspopovic, Ziga Jan, James Sharpe.

Abstract

We have created a 2D morphometric analysis of the developing mouse hindlimb bud. This analysis has provided two useful resources for the study of limb development. First, a temporally accurate numerical description of shape changes during normal mouse limb development. Second, a web-based morphometric staging system, which has the advantage of being easy to use, and with a reproducibility of about ±2 hours. It allows users to upload a dorsal-view photo of a limb bud, draw a spline curve and thereby stage the bud within a couple of minutes. We describe how the system is constructed, its robustness to user variation and illustrate one application: the accurate tracking of spatiotemporal dynamics of gene expression patterns.

Entities: Gene Species

Mesh：

Substances：

Year: 2011 PMID： 21307091 PMCID： PMC3042875 DOI： 10.1242/dev.057547

Source DB: PubMed Journal: Development ISSN： 0950-1991 Impact factor: 6.868

9 in total

1. A series of normal stages in the development of the chick embryo. 1951.

Authors: V Hamburger; H L Hamilton
Journal: Dev Dyn Date: 1992-12 Impact factor: 3.780

2. A staging system for mouse limb development.

Authors: N Wanek; K Muneoka; G Holler-Dinsmore; R Burton; S V Bryant
Journal: J Exp Zool Date: 1989-01

3. The timing and sequence of events in the development of the human respiratory system during the embryonic period proper.

Authors: R O'Rahilly; E A Boyden
Journal: Z Anat Entwicklungsgesch Date: 1973

4. The timing and sequence of events in the development of the human eye and ear during the embryonic period proper.

Authors: R O'Rahilly
Journal: Anat Embryol (Berl) Date: 1983

5. The role of spatially controlled cell proliferation in limb bud morphogenesis.

Authors: Bernd Boehm; Henrik Westerberg; Gaja Lesnicar-Pucko; Sahdia Raja; Michael Rautschka; James Cotterell; Jim Swoger; James Sharpe
Journal: PLoS Biol Date: 2010-07-13 Impact factor: 8.029

6. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.

Authors: Odyssé Michos; Lia Panman; Kristina Vintersten; Konstantin Beier; Rolf Zeller; Aimée Zuniga
Journal: Development Date: 2004-06-16 Impact factor: 6.868

7. A real mouse for your computer.

Authors: R Baldock; J Bard; M Kaufman; D Davidson
Journal: Bioessays Date: 1992-07 Impact factor: 4.345

8. Optical projection tomography as a tool for 3D microscopy and gene expression studies.

Authors: James Sharpe; Ulf Ahlgren; Paul Perry; Bill Hill; Allyson Ross; Jacob Hecksher-Sørensen; Richard Baldock; Duncan Davidson
Journal: Science Date: 2002-04-19 Impact factor: 47.728

9. A computational clonal analysis of the developing mouse limb bud.

Authors: Luciano Marcon; Carlos G Arqués; Miguel S Torres; James Sharpe
Journal: PLoS Comput Biol Date: 2011-02-10 Impact factor: 4.475

9 in total

12 in total

1. 4D atlas of the mouse embryo for precise morphological staging.

Authors: Michael D Wong; Matthijs C van Eede; Shoshana Spring; Stefan Jevtic; Julia C Boughner; Jason P Lerch; R Mark Henkelman
Journal: Development Date: 2015-10-15 Impact factor: 6.868

2. Embryonic craniofacial bone volume and bone mineral density in Fgfr2(+/P253R) and nonmutant mice.

Authors: Christopher J Percival; Yuan Huang; Ethylin Wang Jabs; Runze Li; Joan T Richtsmeier
Journal: Dev Dyn Date: 2014-02-07 Impact factor: 3.780

3. Quantification of shape and cell polarity reveals a novel mechanism underlying malformations resulting from related FGF mutations during facial morphogenesis.

Authors: Xin Li; Nathan M Young; Stephen Tropp; Diane Hu; Yanhua Xu; Benedikt Hallgrímsson; Ralph S Marcucio
Journal: Hum Mol Genet Date: 2013-08-01 Impact factor: 6.150

A landmark-free morphometric staging system for the mouse limb bud.

1. A series of normal stages in the development of the chick embryo. 1951.

2. A staging system for mouse limb development.

3. The timing and sequence of events in the development of the human respiratory system during the embryonic period proper.

4. The timing and sequence of events in the development of the human eye and ear during the embryonic period proper.

5. The role of spatially controlled cell proliferation in limb bud morphogenesis.

6. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.

7. A real mouse for your computer.

8. Optical projection tomography as a tool for 3D microscopy and gene expression studies.

9. A computational clonal analysis of the developing mouse limb bud.

1. 4D atlas of the mouse embryo for precise morphological staging.

2. Embryonic craniofacial bone volume and bone mineral density in Fgfr2(+/P253R) and nonmutant mice.

3. Quantification of shape and cell polarity reveals a novel mechanism underlying malformations resulting from related FGF mutations during facial morphogenesis.

4. It takes two: Building the vertebrate skull from chondrocranium and dermatocranium.

5. A quantitative method for staging mouse embryos based on limb morphometry.

6. A computational clonal analysis of the developing mouse limb bud.

7. Data-driven modelling of a gene regulatory network for cell fate decisions in the growing limb bud.

8. Geometric Morphometrics on Gene Expression Patterns Within Phenotypes: A Case Example on Limb Development.

9. A staging system for correct phenotype interpretation of mouse embryos harvested on embryonic day 14 (E14.5).

10. Representation of anatomy in online atlases and databases: a survey and collection of patterns for interface design.