BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an inflammatory systemic disease associated with numerous extrapulmonary manifestations. Amongst these is an increased risk for cardiovascular disease. The mechanisms for this association remain unclear. We sought to examine lipid trends in a well-characterized cohort of patients with severe COPD. METHODS: We conducted a retrospective prospective analysis of 126 consecutive individuals evaluated for lung transplantation with a diagnosis of COPD in whom lipid values were available. Observed lipid values were compared with a reference population without severe COPD. RESULTS: Compared with the reference population, mean low-density lipoprotein cholesterol (LDL-C) levels were slightly reduced at 108 ± 44 vs 117 ± 29.5 mg/dl (p = 0.02) in men but were no different in women. Mean high-density lipoprotein cholesterol (HDL-C) levels were significantly elevated at 62 ± 24 vs 45 ± 12 mg/dl (p < 0.0001) in men and at 83 ± 27 vs 59 ± 16 mg/dl in women (p < 0.0001). Prednisone use correlated with higher HDL-C levels but did not fully explain the extent of elevation. Angiographically proven coronary artery disease was found in 61% of individuals and was unrelated to HDL-C levels. CONCLUSIONS: Severe COPD is associated with increased levels of HDL-C, which is partially attributable to oral steroid use. HDL-C in this population is not associated with reduced risk of angiographically proven coronary artery disease.
BACKGROUND:Chronic obstructive pulmonary disease (COPD) is an inflammatory systemic disease associated with numerous extrapulmonary manifestations. Amongst these is an increased risk for cardiovascular disease. The mechanisms for this association remain unclear. We sought to examine lipid trends in a well-characterized cohort of patients with severe COPD. METHODS: We conducted a retrospective prospective analysis of 126 consecutive individuals evaluated for lung transplantation with a diagnosis of COPD in whom lipid values were available. Observed lipid values were compared with a reference population without severe COPD. RESULTS: Compared with the reference population, mean low-density lipoprotein cholesterol (LDL-C) levels were slightly reduced at 108 ± 44 vs 117 ± 29.5 mg/dl (p = 0.02) in men but were no different in women. Mean high-density lipoprotein cholesterol (HDL-C) levels were significantly elevated at 62 ± 24 vs 45 ± 12 mg/dl (p < 0.0001) in men and at 83 ± 27 vs 59 ± 16 mg/dl in women (p < 0.0001). Prednisone use correlated with higher HDL-C levels but did not fully explain the extent of elevation. Angiographically proven coronary artery disease was found in 61% of individuals and was unrelated to HDL-C levels. CONCLUSIONS: Severe COPD is associated with increased levels of HDL-C, which is partially attributable to oral steroid use. HDL-C in this population is not associated with reduced risk of angiographically proven coronary artery disease.
Authors: Robert M Reed; Michael Eberlein; Reda E Girgis; Salman Hashmi; Aldo Iacono; Steven Jones; Giora Netzer; Steven Scharf Journal: Am J Med Date: 2012-09-06 Impact factor: 4.965
Authors: Kristin M Burkart; Ani Manichaikul; Jemma B Wilk; Firas S Ahmed; Gregory L Burke; Paul Enright; Nadia N Hansel; Demondes Haynes; Susan R Heckbert; Eric A Hoffman; Joel D Kaufman; Jun Kurai; Laura Loehr; Stephanie J London; Yang Meng; George T O'Connor; Elizabeth Oelsner; Marcy Petrini; Tess D Pottinger; Charles A Powell; Susan Redline; Jerome I Rotter; Lewis J Smith; María Soler Artigas; Martin D Tobin; Michael Y Tsai; Karol Watson; Wendy White; Taylor R Young; Stephen S Rich; R Graham Barr Journal: Eur Respir J Date: 2013-07-30 Impact factor: 16.671
Authors: Ma'en Obeidat; Nick Fishbane; Yunlong Nie; Virginia Chen; Zsuzsanna Hollander; Scott J Tebbutt; Yohan Bossé; Raymond T Ng; Bruce E Miller; Bruce McManus; Stephen Rennard; Peter D Paré; Don D Sin Journal: PLoS One Date: 2015-10-13 Impact factor: 3.240
Authors: Robert M Reed; Saif M Borgan; Michael Eberlein; Monica Goldklang; Joshua Lewis; Michael Miller; Mohamad Navab; Bo S Kim Journal: Int J Biomed Sci Date: 2017-03