| Literature DB >> 21306904 |
John Spencer1, Rajendra P Rathnam, Alan L Harvey, Carol J Clements, Rachel L Clark, Michael P Barrett, Pui Ee Wong, Louise Male, Simon J Coles, Simon P Mackay.
Abstract
A library of 1,4-benzodiazepines has been synthesized and evaluated against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis. Benzodiazepines possessing a P2- transporter motif were found to have MIC values as low as 0.78 μM.Entities:
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Year: 2011 PMID： 21306904 DOI： 10.1016/j.bmc.2011.01.010
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641