Literature DB >> 21306129

Inhibitors of the oncogenic transcription factor AP-1 from Podocarpus latifolius.

Krishna P Devkota1, Ranjala Ratnayake, Nancy H Colburn, Jennifer A Wilson, Curtis J Henrich, James B McMahon, John A Beutler.   

Abstract

An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.

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Year:  2011        PMID： 21306129      PMCID： PMC3064712          DOI： 10.1021/np100736y

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

Review 1.  The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.

Authors:  P Angel; M Karin
Journal:  Biochim Biophys Acta       Date:  1991-12-10

2.  A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1.

Authors:  Katie M Ruocco; Ekaterina I Goncharova; Matthew R Young; Nancy H Colburn; James B McMahon; Curtis J Henrich
Journal:  J Biomol Screen       Date:  2006-12-14

3.  Automatic column chromatographic method for insect-moulting steroids.

Authors:  M Hori
Journal:  Steroids       Date:  1969-07       Impact factor: 2.668

4.  Cytotoxic diterpenoids from Podocarpus madagascariensis from the Madagascar rainforest.

Authors:  Micah Reynolds; V S Prakash Chaturvedula; Fidisoa Ratovoson; Rabodo Andriantsiferana; Vincent E Rasamison; Rebecca C Guza; David G I Kingston
Journal:  Nat Prod Res       Date:  2006-05-20       Impact factor: 2.861

5.  Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.

Authors:  M R Young; J J Li; M Rincón; R A Flavell; B K Sathyanarayana; R Hunziker; N Colburn
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

6.  Antibacterial novel phenolic diterpenes from Podocarpus macrophyllus D. Don.

Authors:  Kimihiko Sato; Keito Sugawara; Hirono Takeuchi; Hyun-Sun Park; Toshiyuki Akiyama; Tetsuo Koyama; Yutaka Aoyagi; Koichi Takeya; Takanori Tsugane; Susumu Shimura
Journal:  Chem Pharm Bull (Tokyo)       Date:  2008-12       Impact factor: 1.645

7.  Cytotoxic bisnor- and norditerpene dilactones having 7alpha,8alpha-epoxy-9,11-enolide substructure from Podocarpus macrophyllus D. DON.

Authors:  Kimihiko Sato; Yasunori Inaba; Hyun-Sun Park; Toshiyuki Akiyama; Tetsuo Koyama; Haruhiko Fukaya; Yutaka Aoyagi; Koichi Takeya
Journal:  Chem Pharm Bull (Tokyo)       Date:  2009-07       Impact factor: 1.645

8.  Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

Authors:  P H Brown; R Alani; L H Preis; E Szabo; M J Birrer
Journal:  Oncogene       Date:  1993-04       Impact factor: 9.867

9.  Cytotoxic constituents from Podocarpus fasciculus.

Authors:  Yu-Jen Kuo; Shy-Yuan Hwang; Ming-Der Wu; Chia-Ching Liao; Yu-Han Liang; Yao-Haur Kuo; Hsiu-O Ho
Journal:  Chem Pharm Bull (Tokyo)       Date:  2008-04       Impact factor: 1.645

10.  High throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules.

Authors:  Thomas G McCloud
Journal:  Molecules       Date:  2010-06-24       Impact factor: 4.411
  10 in total
  3 in total

1.  Coupling of sterically hindered trisubstituted olefins and benzocyclobutenones by C-C activation: total synthesis and structural revision of cycloinumakiol.

Authors:  Tao Xu; Guangbin Dong
Journal:  Angew Chem Int Ed Engl       Date:  2014-08-19       Impact factor: 15.336

2.  Deconstructive Synthesis of Bridged and Fused Rings via Transition-Metal-Catalyzed "Cut-and-Sew" Reactions of Benzocyclobutenones and Cyclobutanones.

Authors:  Yibin Xue; Guangbin Dong
Journal:  Acc Chem Res       Date:  2022-07-28       Impact factor: 24.466

3.  Small molecule inhibitors targeting activator protein 1 (AP-1).

Authors:  Na Ye; Ye Ding; Christopher Wild; Qiang Shen; Jia Zhou
Journal:  J Med Chem       Date:  2014-05-27       Impact factor: 8.039
  3 in total

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