Literature DB >> 21304505

Therapy: Spleen tyrosine kinase inhibitors--novel therapies for RA?

José A Gómez-Puerta1, Xavier Bosch.   

Abstract

In patients with active rheumatoid arthritis despite therapy with DMARDS, treatment with a spleen tyrosine kinase inhibitor has achieved similar response rates to those achieved in clinical trials of other drugs, including biologic agents. Where might these agents fit in the current armamentarium against this disease?

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Year:  2011        PMID: 21304505     DOI: 10.1038/nrrheum.2011.8

Source DB:  PubMed          Journal:  Nat Rev Rheumatol        ISSN: 1759-4790            Impact factor:   20.543


  10 in total

1.  An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents.

Authors:  Mark C Genovese; Arthur Kavanaugh; Michael E Weinblatt; Charles Peterfy; Julie DiCarlo; Michael L White; Maryann O'Brien; Elliott B Grossbard; Daniel B Magilavy
Journal:  Arthritis Rheum       Date:  2011-02

Review 2.  Spleen tyrosine kinases: biology, therapeutic targets and drugs.

Authors:  Mauro Riccaboni; Ivana Bianchi; Paola Petrillo
Journal:  Drug Discov Today       Date:  2010-05-27       Impact factor: 7.851

3.  Healing the Syk through kinase inhibitors.

Authors:  Juan Rivera; Robert A Colbert
Journal:  N Engl J Med       Date:  2010-09-22       Impact factor: 91.245

4.  An oral spleen tyrosine kinase (Syk) inhibitor for rheumatoid arthritis.

Authors:  Michael E Weinblatt; Arthur Kavanaugh; Mark C Genovese; Theresa K Musser; Elliott B Grossbard; Daniel B Magilavy
Journal:  N Engl J Med       Date:  2010-09-22       Impact factor: 91.245

5.  Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor.

Authors:  Polly R Pine; Betty Chang; Nathan Schoettler; Mona L Banquerigo; Su Wang; Angela Lau; Feifei Zhao; Elliott B Grossbard; Donald G Payan; Ernest Brahn
Journal:  Clin Immunol       Date:  2007-05-29       Impact factor: 3.969

Review 6.  State-of-the-art: rheumatoid arthritis.

Authors:  Iain B McInnes; James R O'Dell
Journal:  Ann Rheum Dis       Date:  2010-11       Impact factor: 19.103

Review 7.  Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis.

Authors:  Malini Bajpai; Puneet Chopra; Sunanda G Dastidar; Abhijit Ray
Journal:  Expert Opin Investig Drugs       Date:  2008-05       Impact factor: 6.206

8.  An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus.

Authors:  Frances Rena Bahjat; Polly R Pine; Andrea Reitsma; Gail Cassafer; Muhammad Baluom; Sunny Grillo; Betty Chang; Fei Fei Zhao; Donald G Payan; Elliott B Grossbard; David I Daikh
Journal:  Arthritis Rheum       Date:  2008-05

9.  Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial.

Authors:  Michael E Weinblatt; Arthur Kavanaugh; Ruben Burgos-Vargas; Ara H Dikranian; Gabriel Medrano-Ramirez; Jorge L Morales-Torres; Frederick T Murphy; Theresa Kane Musser; Nicholas Straniero; Angela V Vicente-Gonzales; Elliott Grossbard
Journal:  Arthritis Rheum       Date:  2008-11

Review 10.  Management of adverse events associated with tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia.

Authors:  E Jabbour; M Deininger; A Hochhaus
Journal:  Leukemia       Date:  2010-09-23       Impact factor: 11.528

  10 in total
  4 in total

1.  Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.

Authors:  Huiying Zhi; Jing Dai; Junling Liu; Jieqing Zhu; Debra K Newman; Cunji Gao; Peter J Newman
Journal:  PLoS One       Date:  2015-08-20       Impact factor: 3.240

2.  RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis.

Authors:  Naoko Yagishita; Satoko Aratani; Craig Leach; Tetsuya Amano; Yoshihisa Yamano; Ko Nakatani; Kusuki Nishioka; Toshihiro Nakajima
Journal:  Int J Mol Med       Date:  2012-09-18       Impact factor: 4.101

Review 3.  Syk inhibitors in clinical development for hematological malignancies.

Authors:  Delong Liu; Aleksandra Mamorska-Dyga
Journal:  J Hematol Oncol       Date:  2017-07-28       Impact factor: 17.388

Review 4.  Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis.

Authors:  Jose A Gomez-Puerta; Attila Mócsai
Journal:  Curr Top Med Chem       Date:  2013       Impact factor: 3.295

  4 in total

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