BACKGROUND AND AIMS: Early detection is an essential prognostic factor in colorectal cancer (CRC) recurrence. Our aim was to evaluate diagnostic performances of (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-FDG-PET)/computed tomography (CT) as compared with CT in the detection of CRC recurrence. METHODS: Data of patients with suspected CRC recurrence and in whom both FDG-PET/CT and CT were performed were analyzed. All detected lesions were characterized according to their number, size, and localization. Positive histological or radiological follow-up was considered as the 'gold standard'. Diagnostic performances of FDG-PET/CT and CT were calculated by lesion, globally and with respect to the site of recurrence. RESULTS: One hundred and seventy-six true-positive lesions were identified in 71 patients. CT scan was positive in 58 (82%) patients and FDG-PET/CT in 70 (98%) patients. In per lesion analysis, the global accuracy of FDG-PET/CT in detection of lesions was of 88% (sensitivity = 95%, specificity = 54%), which was higher than that of CT (53%, sensitivity = 55%, specificity = 43%), particularly in case of lymph nodes metastases (100 vs. 35%) and locoregional lesions (100 vs. 39%) (P<0.0001). FDG-PET/CT modified the clinical management in 31 patients. CONCLUSIONS: FDG-PET/CT is more sensitive than CT for diagnosis of CRC recurrence and can modify the management in 40% of patients.
BACKGROUND AND AIMS: Early detection is an essential prognostic factor in colorectal cancer (CRC) recurrence. Our aim was to evaluate diagnostic performances of (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-FDG-PET)/computed tomography (CT) as compared with CT in the detection of CRC recurrence. METHODS: Data of patients with suspected CRC recurrence and in whom both FDG-PET/CT and CT were performed were analyzed. All detected lesions were characterized according to their number, size, and localization. Positive histological or radiological follow-up was considered as the 'gold standard'. Diagnostic performances of FDG-PET/CT and CT were calculated by lesion, globally and with respect to the site of recurrence. RESULTS: One hundred and seventy-six true-positive lesions were identified in 71 patients. CT scan was positive in 58 (82%) patients and FDG-PET/CT in 70 (98%) patients. In per lesion analysis, the global accuracy of FDG-PET/CT in detection of lesions was of 88% (sensitivity = 95%, specificity = 54%), which was higher than that of CT (53%, sensitivity = 55%, specificity = 43%), particularly in case of lymph nodes metastases (100 vs. 35%) and locoregional lesions (100 vs. 39%) (P<0.0001). FDG-PET/CT modified the clinical management in 31 patients. CONCLUSIONS: FDG-PET/CT is more sensitive than CT for diagnosis of CRC recurrence and can modify the management in 40% of patients.
Authors: Y Touchefeu; C Bailly; E Frampas; T Eugène; C Rousseau; M Bourgeois; C Bossard; A Faivre-Chauvet; A Rauscher; D Masson; A David; E Cerato; T Carlier; R M Sharkey; D M Goldenberg; J Barbet; F Kraeber-Bodere; C Bodet-Milin Journal: Eur J Nucl Med Mol Imaging Date: 2020-08-21 Impact factor: 9.236
Authors: Gabriela M Vargas; Kristin M Sheffield; Abhishek D Parmar; Yimei Han; Kimberly M Brown; Taylor S Riall Journal: Surgery Date: 2013-08 Impact factor: 3.982
Authors: C Brendle; N F Schwenzer; H Rempp; H Schmidt; C Pfannenberg; C la Fougère; K Nikolaou; C Schraml Journal: Eur J Nucl Med Mol Imaging Date: 2015-07-31 Impact factor: 9.236
Authors: Roberto García-Figueiras; Sandra Baleato-González; Anwar R Padhani; Ana Marhuenda; Antonio Luna; Lidia Alcalá; Ana Carballo-Castro; Ana Álvarez-Castro Journal: Insights Imaging Date: 2016-04-30