Literature DB >> 21302301

C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells.

Berta Henriquez1, Matias Hepp, Paola Merino, Hugo Sepulveda, Andre J van Wijnen, Jane B Lian, Gary S Stein, Janet L Stein, Martin Montecino.   

Abstract

The Runx2 factor is an essential component of the regulatory mechanisms that control transcription during skeletogenesis. Runx2/p57 expression in osteoblastic cells is controlled by the P1 promoter, which is recognized by key regulators of osteoblast differentiation including homeodomain factors and Wnt- and BMP-signaling mediators. Here, we report that the transcription factor C/EBPβ up-regulates Runx2/p57 expression by directly binding to the Runx2 P1 promoter in mesenchymal, pre-osteoblastic, and osteoblastic cells. This C/EBPβ-mediated up-regulation is principally dependent on C/EBP site II that is located within the first 180 bp of the proximal P1 promoter region and is highly conserved among mouse, rat, and human Runx2 genes. Our studies reveal how the C/EBPβ factor, known to have a key role during osteogenesis, contributes to regulating the expression of Runx2, the master regulator of osteoblast differentiation.
Copyright © 2011 Wiley-Liss, Inc.

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Year:  2011        PMID： 21302301      PMCID： PMC3449309          DOI： 10.1002/jcp.22652

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  43 in total

1.  Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis by alternative translational initiation at multiple AUG start sites.

Authors:  W Xiong; C C Hsieh; A J Kurtz; J P Rabek; J Papaconstantinou
Journal:  Nucleic Acids Res       Date:  2001-07-15       Impact factor: 16.971

2.  Coordination of PIC assembly and chromatin remodeling during differentiation-induced gene activation.

Authors:  Evi Soutoglou; Iannis Talianidis
Journal:  Science       Date:  2002-03-08       Impact factor: 47.728

3.  CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression.

Authors:  Soraya Gutierrez; Amjad Javed; Daniel K Tennant; Monique van Rees; Martin Montecino; Gary S Stein; Janet L Stein; Jane B Lian
Journal:  J Biol Chem       Date:  2001-10-19       Impact factor: 5.157

Review 4.  CCAAT/enhancer-binding proteins: structure, function and regulation.

Authors:  Dipak P Ramji; Pelagia Foka
Journal:  Biochem J       Date:  2002-08-01       Impact factor: 3.857

5.  Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling.

Authors:  Roberto Paredes; José Gutiérrez; Soraya Gutierrez; Lizabeth Allison; Marcia Puchi; Maria Imschenetzky; Andre van Wijnen; Jane Lian; Gary Stein; Janet Stein; Martin Montecino
Journal:  Biochem J       Date:  2002-05-01       Impact factor: 3.857

Review 6.  Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors.

Authors:  Jane B Lian; Amjad Javed; S Kaleem Zaidi; Christopher Lengner; Martin Montecino; Andre J van Wijnen; Janet L Stein; Gary S Stein
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2004       Impact factor: 1.807

7.  Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells.

Authors:  Roberto Paredes; Gloria Arriagada; Fernando Cruzat; Alejandro Villagra; Juan Olate; Kaleem Zaidi; Andre van Wijnen; Jane B Lian; Gary S Stein; Janet L Stein; Martin Montecino
Journal:  Mol Cell Biol       Date:  2004-10       Impact factor: 4.272

8.  Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity.

Authors:  Jose Sierra; Alejandro Villagra; Roberto Paredes; Fernando Cruzat; Soraya Gutierrez; Amjad Javed; Gloria Arriagada; Juan Olate; Maria Imschenetzky; Andre J Van Wijnen; Jane B Lian; Gary S Stein; Janet L Stein; Martin Montecino
Journal:  Mol Cell Biol       Date:  2003-05       Impact factor: 4.272

9.  Ras induces mediator complex exchange on C/EBP beta.

Authors:  Xianming Mo; Elisabeth Kowenz-Leutz; Hong Xu; Achim Leutz
Journal:  Mol Cell       Date:  2004-01-30       Impact factor: 17.970

10.  Characterization of an osteoblast-specific enhancer element in the CBFA1 gene.

Authors:  Adriana Zambotti; Huda Makhluf; Jianhe Shen; Patricia Ducy
Journal:  J Biol Chem       Date:  2002-08-16       Impact factor: 5.157
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  18 in total

Review 1.  Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts.

Authors:  Maya Fakhry; Eva Hamade; Bassam Badran; René Buchet; David Magne
Journal:  World J Stem Cells       Date:  2013-10-26       Impact factor: 5.326

2.  Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene.

Authors:  Hayk Hovhannisyan; Ying Zhang; Mohammad Q Hassan; Hai Wu; Carlotta Glackin; Jane B Lian; Janet L Stein; Martin Montecino; Gary S Stein; Andre J van Wijnen
Journal:  J Cell Physiol       Date:  2013-02       Impact factor: 6.384

3.  The Ric-8B gene is highly expressed in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and C/EBPbeta-mediated manner.

Authors:  Rodrigo Grandy; Hugo Sepulveda; Rodrigo Aguilar; Philippe Pihan; Berta Henriquez; Juan Olate; Martin Montecino
Journal:  Mol Cell Biol       Date:  2011-05-23       Impact factor: 4.272

4.  A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts.

Authors:  Rodrigo Aguilar; Rodrigo Grandy; Daniel Meza; Hugo Sepulveda; Philippe Pihan; Andre J van Wijnen; Jane B Lian; Gary S Stein; Janet L Stein; Martin Montecino
Journal:  J Cell Physiol       Date:  2014-10       Impact factor: 6.384

5.  The secreted protein DEL-1 activates a β3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration.

Authors:  Da-Yo Yuh; Tomoki Maekawa; Xiaofei Li; Tetsuhiro Kajikawa; Khalil Bdeir; Triantafyllos Chavakis; George Hajishengallis
Journal:  J Biol Chem       Date:  2020-04-12       Impact factor: 5.157

6.  Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.

Authors:  Adriana Rojas; Rodrigo Aguilar; Berta Henriquez; Jane B Lian; Janet L Stein; Gary S Stein; Andre J van Wijnen; Brigitte van Zundert; Miguel L Allende; Martin Montecino
Journal:  J Biol Chem       Date:  2015-10-09       Impact factor: 5.157

7.  Epigenetic landscape during osteoblastogenesis defines a differentiation-dependent Runx2 promoter region.

Authors:  Phillip W L Tai; Hai Wu; Jonathan A R Gordon; Troy W Whitfield; A Rasim Barutcu; André J van Wijnen; Jane B Lian; Gary S Stein; Janet L Stein
Journal:  Gene       Date:  2014-06-02       Impact factor: 3.688

8.  Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus.

Authors:  Rodrigo Aguilar; Fernando J Bustos; Mauricio Saez; Adriana Rojas; Miguel L Allende; Andre J van Wijnen; Brigitte van Zundert; Martin Montecino
Journal:  Biochim Biophys Acta       Date:  2016-05-20

9.  Cancer-Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer.

Authors:  Aimy Sebastian; Nicholas R Hum; Bryan D Hudson; Gabriela G Loots
Journal:  Microarrays (Basel)       Date:  2015-10-29

10.  Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress.

Authors:  Carlos Farkas; Carla P Martins; David Escobar; Matias I Hepp; Ariel F Castro; Gerard Evan; José L Gutiérrez; Robert Warren; David B Donner; Roxana Pincheira
Journal:  PLoS One       Date:  2013-09-06       Impact factor: 3.240
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