| Literature DB >> 21302066 |
M Seman1, V Zilberfarb, M Stanislawski, J M Dubert.
Abstract
A low IgG2a response in B10 mice during the primary response to sheep red blood cells (SRBC) is described. Analysis of the response in B10 × BALB/c hybrid progenies and in congenic strains indicates that this low response is a dominant phenotype placed under the control of a single Mendelian gene or a group of closely linked genes. This gene(s) is neither linked to CH allotypes orH2 haplotypes, nor is it sex-linked. It can be considered as an isotype- and antigenspecific regulatory gene of the immune response.Entities:
Year: 1978 PMID: 21302066 DOI: 10.1007/BF01843998
Source DB: PubMed Journal: Immunogenetics ISSN: 0093-7711 Impact factor: 2.846