Literature DB >> 21302026

Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection.

Ann B Ragin1, Ying Wu, Renee Ochs, Hongyan Du, Leon G Epstein, Katherine Conant, Justin C McArthur.   

Abstract

Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.

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Year:  2011        PMID： 21302026      PMCID： PMC3771512          DOI： 10.1007/s13365-011-0018-5

Source DB:  PubMed          Journal:  J Neurovirol        ISSN： 1355-0284            Impact factor:   2.643


  32 in total

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5.  Heparan sulfate proteoglycans as extracellular docking molecules for matrilysin (matrix metalloproteinase 7).

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Journal:  J Biol Chem       Date:  2000-02-11       Impact factor: 5.157

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8.  Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus.

Authors:  Ann B Ragin; Ying Wu; Pippa Storey; Bruce A Cohen; Robert R Edelman; Leon G Epstein
Journal:  J Neurovirol       Date:  2005-07       Impact factor: 2.643

9.  Diffusion alterations in corpus callosum of patients with HIV.

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Journal:  AJNR Am J Neuroradiol       Date:  2006-03       Impact factor: 3.825

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  8 in total

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Journal:  J Neurovirol       Date:  2011-09-29       Impact factor: 2.643

Review 2.  Dynamic nature of the p75 neurotrophin receptor in response to injury and disease.

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Journal:  J Neuroimmune Pharmacol       Date:  2014-09-20       Impact factor: 4.147

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6.  Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status.

Authors:  Suyang Li; Ying Wu; Sheila M Keating; Hongyan Du; Christina L Sammet; Cindy Zadikoff; Riti Mahadevia; Leon G Epstein; Ann B Ragin
Journal:  J Neurovirol       Date:  2013-08-27       Impact factor: 2.643

7.  Relationship between Cerebrospinal Fluid Matrix Metalloproteinases Levels and Brain Amyloid Deposition in Mild Cognitive Impairment.

Authors:  Yuuki Sasaki; Noriyuki Kimura; Yasuhiro Aso; Kenichi Yabuuchi; Miki Aikawa; Etsuro Matsubara
Journal:  Biomolecules       Date:  2021-10-11

8.  Determinants of HIV-induced brain changes in three different periods of the early clinical course: A data mining analysis.

Authors:  Bokai Cao; Xiangnan Kong; Casey Kettering; Philip Yu; Ann Ragin
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  8 in total

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