| Literature DB >> 21301807 |
C F Gomez1, L Constantine, M Moen, A Vaz, W Wang, Duane B Huggett.
Abstract
The presence of pharmaceuticals in the environment has become an important topic of discussion with respect to pharmaceutical absorption, metabolism and elimination in fish. This study investigates the metabolism of ibuprofen by rainbow trout (Oncorhynchus mykiss). In vitro metabolic loss of parent compound was measured in gill and liver S9 and microsomal fractions. Metabolite analysis found 2-hydroxy-ibuprofen as the major metabolite in uninduced S9 fractions. Supplementing S9 fractions with UDPGA did not significantly enhance metabolism. Additionally, assays involving the induction and inhibition of specific CYP isozymes support CYP1A2 as a possible metabolic pathway in fish.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21301807 DOI： 10.1007/s00128-011-0200-8
Source DB: PubMed Journal: Bull Environ Contam Toxicol ISSN： 0007-4861 Impact factor: 2.151