Literature DB >> 21301220

A model of the C14-EPIC complex indicates hotspots for a protease-inhibitor arms race in the oomycete-potato interaction.

Farnusch Kaschani1, Renier A L Van der Hoorn.   

Abstract

The oomycete pathogen Phytophthora infestans secretes cystatin-like effector proteins (EPICs) that inhibit secreted host proteases during infection. We recently found that the C14 protease is a relevant target of EPICs and that this protease is under diversifying selection in wild potato species with which P. infestans has coevolved. Here we generated a model of the EPIC-C14 complex based on cystatin-papain crystal structures and discovered three regions where variant residues in C14 might be the result of an arms race between enzyme and inhibitor at the plant-pathogen interface.

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Year:  2011        PMID： 21301220      PMCID： PMC3122019          DOI： 10.4161/psb.6.1.14190

Source DB:  PubMed          Journal:  Plant Signal Behav        ISSN： 1559-2316


  16 in total

1.  Structure validation by Calpha geometry: phi,psi and Cbeta deviation.

Authors:  Simon C Lovell; Ian W Davis; W Bryan Arendall; Paul I W de Bakker; J Michael Word; Michael G Prisant; Jane S Richardson; David C Richardson
Journal:  Proteins       Date:  2003-02-15

Review 2.  Enzyme-inhibitor interactions at the plant-pathogen interface.

Authors:  Johana C Misas-Villamil; Renier A L van der Hoorn
Journal:  Curr Opin Plant Biol       Date:  2008-06-10       Impact factor: 7.834

3.  A Phytophthora infestans cystatin-like protein targets a novel tomato papain-like apoplastic protease.

Authors:  Miaoying Tian; Joe Win; Jing Song; Renier van der Hoorn; Esther van der Knaap; Sophien Kamoun
Journal:  Plant Physiol       Date:  2006-11-03       Impact factor: 8.340

4.  An effector-targeted protease contributes to defense against Phytophthora infestans and is under diversifying selection in natural hosts.

Authors:  Farnusch Kaschani; Mohammed Shabab; Tolga Bozkurt; Takayuki Shindo; Sebastian Schornack; Christian Gu; Muhammad Ilyas; Joe Win; Sophien Kamoun; Renier A L van der Hoorn
Journal:  Plant Physiol       Date:  2010-10-12       Impact factor: 8.340

Review 5.  The biology of Phytophthora infestans at its center of origin.

Authors:  Niklaus J Grünwald; Wilbert G Flier
Journal:  Annu Rev Phytopathol       Date:  2005       Impact factor: 13.078

6.  Structure of the glucanase inhibitor protein (GIP) family from phytophthora species suggests coevolution with plant endo-beta-1,3-glucanases.

Authors:  Cynthia M B Damasceno; John G Bishop; Daniel R Ripoll; Joe Win; Sophien Kamoun; Jocelyn K C Rose
Journal:  Mol Plant Microbe Interact       Date:  2008-06       Impact factor: 4.171

7.  Molecular cloning and characterization of glucanase inhibitor proteins: coevolution of a counterdefense mechanism by plant pathogens.

Authors:  Jocelyn K C Rose; Kyung-Sik Ham; Alan G Darvill; Peter Albersheim
Journal:  Plant Cell       Date:  2002-06       Impact factor: 11.277

8.  Phylogeny of wild and cultivatedSolanum species based on nuclear restriction fragment length polymorphisms (RFLPs).

Authors:  T Debener; F Salamini; C Gebhardt
Journal:  Theor Appl Genet       Date:  1990-05       Impact factor: 5.699

9.  The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm.

Authors:  Manuel E Than; Michael Helm; David J Simpson; Friedrich Lottspeich; Robert Huber; Christine Gietl
Journal:  J Mol Biol       Date:  2004-03-05       Impact factor: 5.469

10.  Selection on Glycine beta-1,3-endoglucanase genes differentially inhibited by a Phytophthora glucanase inhibitor protein.

Authors:  J G Bishop; D R Ripoll; S Bashir; C M B Damasceno; J D Seeds; J K C Rose
Journal:  Genetics       Date:  2004-11-15       Impact factor: 4.562
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  6 in total

Review 1.  Phytopathogenic oomycetes: a review focusing on Phytophthora cinnamomi and biotechnological approaches.

Authors:  Darling de Andrade Lourenço; Iuliia Branco; Altino Choupina
Journal:  Mol Biol Rep       Date:  2020-10-17       Impact factor: 2.316

Review 2.  Effectors of Phytophthora pathogens are powerful weapons for manipulating host immunity.

Authors:  Wenjing Wang; Fangchan Jiao
Journal:  Planta       Date:  2019-06-26       Impact factor: 4.116

3.  Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathogen defense.

Authors:  Anja C Hörger; Muhammad Ilyas; Wolfgang Stephan; Aurélien Tellier; Renier A L van der Hoorn; Laura E Rose
Journal:  PLoS Genet       Date:  2012-07-19       Impact factor: 5.917

4.  A role in immunity for Arabidopsis cysteine protease RD21, the ortholog of the tomato immune protease C14.

Authors:  Takayuki Shindo; Johana C Misas-Villamil; Anja C Hörger; Jing Song; Renier A L van der Hoorn
Journal:  PLoS One       Date:  2012-01-06       Impact factor: 3.240

5.  The front line of defence: a meta-analysis of apoplastic proteases in plant immunity.

Authors:  Alice Godson; Renier A L van der Hoorn
Journal:  J Exp Bot       Date:  2021-04-13       Impact factor: 6.992

6.  A cathepsin F-like peptidase involved in barley grain protein mobilization, HvPap-1, is modulated by its own propeptide and by cystatins.

Authors:  Ines Cambra; Manuel Martinez; Beatriz Dáder; Pablo González-Melendi; Jacinto Gandullo; M Estrella Santamaría; Isabel Diaz
Journal:  J Exp Bot       Date:  2012-07-12       Impact factor: 6.992
  6 in total

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