Literature DB >> 21300838

An improved model of the Aspergillus fumigatus CYP51A protein.

M G Fraczek1, M Bromley, P Bowyer.   

Abstract

Azole resistance is an increasing clinical problem for Aspergillus fumigatus, with the majority of published resistance arising from mutations in the azole target gene CYP51A. Previous structural studies of this protein have suffered from a nonorthologous, low-homology template for homology modeling. Here we present a new model based on the human CYP51A orthologue that provides a higher-quality model for A. fumigatus CYP51A.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21300838      PMCID： PMC3088270          DOI： 10.1128/AAC.01651-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis.

Authors:  A Bellamine; A T Mangla; W D Nes; M R Waterman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

2.  Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.

Authors:  L M Podust; T L Poulos; M R Waterman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-13       Impact factor: 11.205

Review 3.  The biodiversity of microbial cytochromes P450.

Authors:  Steven L Kelly; David C Lamb; Colin J Jackson; Andrew G Warrilow; Diane E Kelly
Journal:  Adv Microb Physiol       Date:  2003       Impact factor: 3.517

4.  Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009.

Authors:  Ahmed Bueid; Susan J Howard; Caroline B Moore; Malcolm D Richardson; Elizabeth Harrison; Paul Bowyer; David W Denning
Journal:  J Antimicrob Chemother       Date:  2010-08-20       Impact factor: 5.790

5.  QMEAN: A comprehensive scoring function for model quality assessment.

Authors:  Pascal Benkert; Silvio C E Tosatto; Dietmar Schomburg
Journal:  Proteins       Date:  2008-04

6.  Azole resistance profile of amino acid changes in Aspergillus fumigatus CYP51A based on protein homology modeling.

Authors:  Eveline Snelders; Anna Karawajczyk; Gijs Schaftenaar; Paul E Verweij; Willem J G Melchers
Journal:  Antimicrob Agents Chemother       Date:  2010-04-12       Impact factor: 5.191

7.  Impact of changes in the target P450 CYP51 enzyme associated with altered triazole-sensitivity in fungal pathogens of cereal crops.

Authors:  H J Cools; B A Fraaije; S H Kim; J A Lucas
Journal:  Biochem Soc Trans       Date:  2006-12       Impact factor: 5.407

8.  Are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola.

Authors:  Hans J Cools; Bart A Fraaije
Journal:  Pest Manag Sci       Date:  2008-07       Impact factor: 4.845

9.  Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.

Authors:  Li Xiao; Vincent Madison; Andrew S Chau; David Loebenberg; Robert E Palermo; Paul M McNicholas
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191

10.  Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism.

Authors:  Eveline Snelders; Henrich A L van der Lee; Judith Kuijpers; Anthonius J M M Rijs; János Varga; Robert A Samson; Emilia Mellado; A Rogier T Donders; Willem J G Melchers; Paul E Verweij
Journal:  PLoS Med       Date:  2008-11-11       Impact factor: 11.069
View more
  14 in total

1.  SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).

Authors:  Sara J Blosser; Robert A Cramer
Journal:  Antimicrob Agents Chemother       Date:  2011-10-17       Impact factor: 5.191

Review 2.  Mechanisms of Antifungal Drug Resistance.

Authors:  Leah E Cowen; Dominique Sanglard; Susan J Howard; P David Rogers; David S Perlin
Journal:  Cold Spring Harb Perspect Med       Date:  2014-11-10       Impact factor: 6.915

Review 3.  The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back.

Authors:  Xiaolei Wei; Yuanwei Zhang; Ling Lu
Journal:  J Microbiol       Date:  2015-01-28       Impact factor: 3.422

4.  An integrated approach for identification and target validation of antifungal compounds active against Erg11p.

Authors:  Dominic Hoepfner; Shantanu Karkare; Stephen B Helliwell; Martin Pfeifer; Markus Trunzer; Sophie De Bonnechose; Alfred Zimmerlin; Jianshi Tao; Daryl Richie; Andreas Hofmann; Stefan Reinker; Mathias Frederiksen; N Rao Movva; Jeffrey A Porter; Neil S Ryder; Christian N Parker
Journal:  Antimicrob Agents Chemother       Date:  2012-05-21       Impact factor: 5.191

5.  Pharmacokinetics of posaconazole within epithelial cells and fungi: insights into potential mechanisms of action during treatment and prophylaxis.

Authors:  Paolo Campoli; David S Perlin; Arnold S Kristof; Theodore C White; Scott G Filler; Donald C Sheppard
Journal:  J Infect Dis       Date:  2013-08-01       Impact factor: 5.226

6.  Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Authors:  Alia A Sagatova; Mikhail V Keniya; Joel D A Tyndall; Brian C Monk
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

Review 7.  Triazole Resistance in Aspergillus Species: An Emerging Problem.

Authors:  Rocio Garcia-Rubio; Manuel Cuenca-Estrella; Emilia Mellado
Journal:  Drugs       Date:  2017-04       Impact factor: 9.546

8.  Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Authors:  Alia A Sagatova; Mikhail V Keniya; Rajni K Wilson; Brian C Monk; Joel D A Tyndall
Journal:  Antimicrob Agents Chemother       Date:  2015-06-08       Impact factor: 5.191

9.  Azole resistance in Aspergillus fumigatus from bronchoalveolar lavage fluid samples of patients with chronic diseases.

Authors:  Yanan Zhao; Christen R Stensvold; David S Perlin; Maiken C Arendrup
Journal:  J Antimicrob Chemother       Date:  2013-03-05       Impact factor: 5.790

10.  Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance.

Authors:  Laura Alcazar-Fuoli; Emilia Mellado
Journal:  Front Microbiol       Date:  2013-01-10       Impact factor: 5.640
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.