Joanna Kałużna-Czaplińska1. 1. Institute of General and Ecological Chemistry, Department of Chemistry, Technical University of Lodz, 116 Zeromskiego Str., 90–924 Lodz, Poland. jkaluzna@p.lodz.pl
Abstract
OBJECTIVES: Quantitative organic acid testing can give information about potential problems, especially with energy production, neurotransmitter metabolism, intestinal dysbiosis and nutritional individuality which is very important in autistic children. The aim of this study was to find out potential differences between the levels of organic acids in the urine of autistic and non-autistic children. DESIGN AND METHODS: The organic acids in the urine were determined by capillary gas chromatography/mass spectrometry (GC/MS). All overnight urine samples were collected from 35 autistic children and 36 neurologically normal children as healthy controls (4-10 years). RESULTS: Significant differences were found between the autistic children and the control group in organic acids: 2-oxoglutaric, isocitric, citric, 4-hydroxybenzoic, 4-hydroxyphenylacetic, hippuric, adipic, suberic (all with p<0.05). CONCLUSION: Organic acids test can be used to assess an individual need for nutrient and biochemical abnormalities, especially important for autistic children.
OBJECTIVES: Quantitative organic acid testing can give information about potential problems, especially with energy production, neurotransmitter metabolism, intestinal dysbiosis and nutritional individuality which is very important in autisticchildren. The aim of this study was to find out potential differences between the levels of organic acids in the urine of autistic and non-autisticchildren. DESIGN AND METHODS: The organic acids in the urine were determined by capillary gas chromatography/mass spectrometry (GC/MS). All overnight urine samples were collected from 35 autisticchildren and 36 neurologically normal children as healthy controls (4-10 years). RESULTS: Significant differences were found between the autisticchildren and the control group in organic acids: 2-oxoglutaric, isocitric, citric, 4-hydroxybenzoic, 4-hydroxyphenylacetic, hippuric, adipic, suberic (all with p<0.05). CONCLUSION:Organic acids test can be used to assess an individual need for nutrient and biochemical abnormalities, especially important for autisticchildren.
Authors: A Stewart Campbell; Brittany D Needham; Christopher R Meyer; Joanna Tan; Mary Conrad; Gregory M Preston; Federico Bolognani; Srinivas G Rao; Helen Heussler; Rebecca Griffith; Adam J Guastella; Amy C Janes; Blaise Frederick; David H Donabedian; Sarkis K Mazmanian Journal: Nat Med Date: 2022-02-14 Impact factor: 53.440