Literature DB >> 21299112

Three new aaptamines from the marine sponge Aaptos sp. and their proapoptotic properties.

Larisa K Shubina1, Tatyana N Makarieva, Sergey A Dyshlovoy, Sergey N Fedorov, Pavel S Dmitrenok, Valentin A Stonik.   

Abstract

Three new aaptamine-type alkaloids, 2,3-dihydro-2,3-dioxoaaptamine (1), 6-(N-morpholinyl)-4,5-dihydro-5-oxo-demethyl(oxy)aaptamine (2) and 3-(methylamino)demethyl(oxy)aaptamine (3), along with known aaptamines were isolated from the sponge Aaptos sp. Their structures were determined on the basis of detailed analysis of their 1D and 2D NMR spectroscopic and mass spectral data. The isolated compounds induced apoptosis in human leukemia THP-1 cells.

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Year:  2010        PMID： 21299112

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  6 in total

1.  Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances.

Authors:  Masayoshi Arai; Chisu Han; Yoshi Yamano; Andi Setiawan; Motomasa Kobayashi
Journal:  J Nat Med       Date:  2014-01-12       Impact factor: 2.343

Review 2.  Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment.

Authors:  Magbubah Essack; Vladimir B Bajic; John A C Archer
Journal:  Mar Drugs       Date:  2011-09-20       Impact factor: 6.085

3.  Mycalamide A shows cytotoxic properties and prevents EGF-induced neoplastic transformation through inhibition of nuclear factors.

Authors:  Sergey A Dyshlovoy; Sergey N Fedorov; Anatoly I Kalinovsky; Larisa K Shubina; Carsten Bokemeyer; Valentin A Stonik; Friedemann Honecker
Journal:  Mar Drugs       Date:  2012-05-30       Impact factor: 6.085

Review 4.  Marine low molecular weight natural products as potential cancer preventive compounds.

Authors:  Valentin A Stonik; Sergey N Fedorov
Journal:  Mar Drugs       Date:  2014-01-27       Impact factor: 5.118

5.  Aaptamines from the marine sponge Aaptos sp. display anticancer activities in human cancer cell lines and modulate AP-1-, NF-κB-, and p53-dependent transcriptional activity in mouse JB6 Cl41 cells.

Authors:  Sergey A Dyshlovoy; Sergey N Fedorov; Larisa K Shubina; Alexandra S Kuzmich; Carsten Bokemeyer; Gunhild Keller-von Amsberg; Friedemann Honecker
Journal:  Biomed Res Int       Date:  2014-07-23       Impact factor: 3.411

Review 6.  Blue-Print Autophagy in 2020: A Critical Review.

Authors:  Sergey A Dyshlovoy
Journal:  Mar Drugs       Date:  2020-09-21       Impact factor: 5.118
  6 in total

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