Literature DB >> 2129899

Molecular mechanisms for lineage commitment in T cell development.

E A Robey1, B J Fowlkes, D M Pardoll.   

Abstract

Thymocyte development is characterized by the ordered expression of T cell receptors as well as the accessory molecules, CD4 and CD8. Interactions of these critical surface molecules with MHC ligands expressed on thymic stromal cells mediate additional developmental processes. Now that the stages of thymic differentiation have been delineated, current investigations are addressing the mechanisms that underlie T cell lineage commitment and selection.

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Year:  1990        PMID： 2129899

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  9 in total

Review 1.  Ligand-dependent regulation of T cell development and activation.

Authors:  Ronald N Germain
Journal:  Immunol Res       Date:  2003       Impact factor: 2.829

2.  Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages.

Authors:  T Crompton; R K Lees; H Pircher; H R MacDonald
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-01       Impact factor: 11.205

3.  Stochastic component to development of class I major histocompatibility complex-specific T cells.

Authors:  A Itano; D Kioussis; E Robey
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-04       Impact factor: 11.205

4.  A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.

Authors:  Y Paquette; L Doyon; A Laperrière; Z Hanna; J Ball; R P Sekaly; P Jolicoeur
Journal:  Mol Cell Biol       Date:  1992-08       Impact factor: 4.272

5.  Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

Authors:  P Borgulya; H Kishi; U Müller; J Kirberg; H von Boehmer
Journal:  EMBO J       Date:  1991-04       Impact factor: 11.598

6.  Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice.

Authors:  E Robey; A Itano; W C Fanslow; B J Fowlkes
Journal:  J Exp Med       Date:  1994-06-01       Impact factor: 14.307

7.  Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer.

Authors:  M D Blum; G T Wong; K M Higgins; M J Sunshine; E Lacy
Journal:  J Exp Med       Date:  1993-05-01       Impact factor: 14.307

8.  Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.

Authors:  D L Wiest; L Yuan; J Jefferson; P Benveniste; M Tsokos; R D Klausner; L H Glimcher; L E Samelson; A Singer
Journal:  J Exp Med       Date:  1993-11-01       Impact factor: 14.307

9.  Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells.

Authors:  J C Zúñiga-Pflücker; H L Schwartz; M J Lenardo
Journal:  J Exp Med       Date:  1993-10-01       Impact factor: 14.307
  9 in total

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