Literature DB >> 21297668

p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.

C Romagosa1, S Simonetti, L López-Vicente, A Mazo, M E Lleonart, J Castellvi, S Ramon y Cajal.   

Abstract

p16(Ink4a) is a protein involved in regulation of the cell cycle. Currently, p16(Ink4a) is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, overexpression of p16(Ink4a) has also been described in several tumors. This review attempts to elucidate when and why p16(Ink4a) overexpression occurs, and to suggest possible implications of p16(Ink4a) in the diagnosis, prognosis and treatment of cancer.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21297668     DOI： 10.1038/onc.2010.614

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  176 in total

1.  Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.

Authors:  Patrick J Roberts; John E Bisi; Jay C Strum; Austin J Combest; David B Darr; Jerry E Usary; William C Zamboni; Kwok-Kin Wong; Charles M Perou; Norman E Sharpless
Journal:  J Natl Cancer Inst       Date:  2012-02-01       Impact factor: 13.506

2.  Stromal p16 expression differentiates endometrial polyp from endometrial hyperplasia.

Authors:  Suzuko Moritani; Shu Ichihara; Masaki Hasegawa; Akari Iwakoshi; Sakae Murakami; Tomoko Sato; Tomomitsu Okamoto; Yoshio Mori; Hajime Kuhara; Steven G Silverberg
Journal:  Virchows Arch       Date:  2012-07-07       Impact factor: 4.064

3.  Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.

Authors:  Ali Khammanivong; Arunkumar Anandharaj; Xuemin Qian; Jung Min Song; Pramod Upadhyaya; Silvia Balbo; Dipankar Bandyopadhyay; Erin B Dickerson; Stephen S Hecht; Fekadu Kassie
Journal:  Mol Carcinog       Date:  2016-01-19       Impact factor: 4.784

4.  Early esophageal squamous cell carcinoma in a western series is not associated with active HPV infection.

Authors:  Christina Kanaan; Diane Lorenzo; Maximilien Barret; Anne Audebourg; Sarah Leblanc; Stanislas Chaussade; Frédéric Prat; Benoît Terris
Journal:  Virchows Arch       Date:  2020-06-10       Impact factor: 4.064

5.  Aberrant expression of p16INK4a in human cancers - a new biomarker?

Authors:  Kazushi Inoue; Elizabeth A Fry
Journal:  Cancer Rep Rev       Date:  2018-01-15

Review 6.  Divide or Conquer: Cell Cycle Regulation of Invasive Behavior.

Authors:  Abraham Q Kohrman; David Q Matus
Journal:  Trends Cell Biol       Date:  2016-09-12       Impact factor: 20.808

Review 7.  A diagnostic algorithm for atypical spitzoid tumors: guidelines for immunohistochemical and molecular assessment.

Authors:  Jeong Hee Cho-Vega
Journal:  Mod Pathol       Date:  2016-04-22       Impact factor: 7.842

8.  Relationship between tumor-associated immune infiltrate and p16 staining over clinicopathological features in acral lentiginous melanoma.

Authors:  C A Castaneda; M Castillo; C Torres-Cabala; L A Bernabe; S Casavilca; V Villegas; J Sanchez; M de la Cruz; J Dunstan; J M Cotrina; H L Gomez; C Chavez; M P Landa-Baella; K Tello; B F Felix; J Abugattas
Journal:  Clin Transl Oncol       Date:  2019-02-16       Impact factor: 3.405

9.  Establishing cut-off points with clinical relevance for bcl-2, cyclin D1, p16, p21, p27, p53, Sox11 and WT1 expression in glioblastoma - a short report.

Authors:  Emma Camacho-Urkaray; Jorge Santos-Juanes; Francisco Borja Gutiérrez-Corres; Beatriz García; Luis M Quirós; Isabel Guerra-Merino; José Javier Aguirre; Iván Fernández-Vega
Journal:  Cell Oncol (Dordr)       Date:  2017-12-07       Impact factor: 6.730

10.  p16 upregulation is linked to poor prognosis in ERG negative prostate cancer.

Authors:  Christoph Burdelski; Tatsiana Dieckmann; Asmus Heumann; Claudia Hube-Magg; Martina Kluth; Burkhard Beyer; Thomas Steuber; Raisa Pompe; Markus Graefen; Ronald Simon; Sarah Minner; Maria Christina Tsourlakis; Christina Koop; Jakob Izbicki; Guido Sauter; Till Krech; Thorsten Schlomm; Waldemar Wilczak; Patrick Lebok
Journal:  Tumour Biol       Date:  2016-07-21
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.