AIM: It has been demonstrated that branched-chain amino acids (BCAA) transaminase activation occurs simultaneously with exercise-induced muscle glycogen reduction, suggesting that BCAA supplementation might play an energetic role in this condition. This study aimed to test whether BCAA supplementation enhances exercise capacity and lipid oxidation in glycogen-depleted subjects. METHODS: Using a double-blind cross-over design, volunteers (N.=7) were randomly assigned to either the BCAA (300 mg . kg . day -1) or the placebo (maltodextrine) for 3 days. On the second day, subjects were submitted to an exercise-induced glycogen depletion protocol. They then performed an exhaustive exercise test on the third day, after which time to exhaustion, respiratory exchange ratio (RER), plasma glucose, free fatty acids (FFA), blood ketones and lactate were determined. BCAA supplementation promoted a greater resistance to fatigue when compared to the placebo (+17.2%). Moreover, subjects supplemented with BCAA showed reduced RER and higher plasma glucose levels during the exhaustive exercise test. CONCLUSION: In conclusion, BCAA supplementation increases resistance to fatigue and enhances lipid oxidation during exercise in glycogen-depleted subjects.
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AIM: It has been demonstrated that branched-chain amino acids (BCAA) transaminase activation occurs simultaneously with exercise-induced muscle glycogen reduction, suggesting that BCAA supplementation might play an energetic role in this condition. This study aimed to test whether BCAA supplementation enhances exercise capacity and lipid oxidation in glycogen-depleted subjects. METHODS: Using a double-blind cross-over design, volunteers (N.=7) were randomly assigned to either the BCAA (300 mg . kg . day -1) or the placebo (maltodextrine) for 3 days. On the second day, subjects were submitted to an exercise-induced glycogen depletion protocol. They then performed an exhaustive exercise test on the third day, after which time to exhaustion, respiratory exchange ratio (RER), plasma glucose, free fatty acids (FFA), blood ketones and lactate were determined. BCAA supplementation promoted a greater resistance to fatigue when compared to the placebo (+17.2%). Moreover, subjects supplemented with BCAA showed reduced RER and higher plasma glucose levels during the exhaustive exercise test. CONCLUSION: In conclusion, BCAA supplementation increases resistance to fatigue and enhances lipid oxidation during exercise in glycogen-depleted subjects.
Authors: Krisztina Marosi; Keelin Moehl; Ignacio Navas-Enamorado; Sarah J Mitchell; Yongqing Zhang; Elin Lehrmann; Miguel A Aon; Sonia Cortassa; Kevin G Becker; Mark P Mattson Journal: FASEB J Date: 2018-02-27 Impact factor: 5.191
Authors: Igor Z Zubrzycki; Zbigniew Ossowski; Stanislaw Przybylski; Magdalena Wiacek; Anna Clarke; Bartosz Trabka Journal: J Int Soc Sports Nutr Date: 2014-11-30 Impact factor: 5.150
Authors: Daniel M Craig; Stephen P Ashcroft; Micah Y Belew; Ben Stocks; Kevin Currell; Keith Baar; Andrew Philp Journal: Front Physiol Date: 2015-10-27 Impact factor: 4.566