BACKGROUND: A prospective follow-up study was conducted to examine the relationship between 9 year change in abdominal obesity and risk of coronary artery calcification (CAC). METHODS: Data on coronary risk factors for 573 postmenopausal women were collected at baseline (1993-1997) and follow-up (2002-2004). At follow-up, the women underwent a multidetector CT to assess coronary calcium using the Agatston score. Markers of abdominal obesity were waist and hip circumference, waist-to-hip ratio (WHR) and body mass index. RESULTS: Compared to subjects whose waist circumference remained below the median at both occasions, those with a waist above the median had a 1.5-fold (95% CI 1.0 to 2.3) increased risk of CAC. Women whose waist rose over the 9 year period had a 2.2-fold (95% CI 1.1 to 4.2) increased risk of CAC, whereas women whose WHR became lower had a non-significant 1.5-fold increased risk of CAC (95% CI 0.7 to 3.0). In contrast, change in body mass index or hip circumference was not related to risk of CAC. CONCLUSION: This study supports the existing evidence that persistent abdominal obesity, as well as an increase in abdominal fat, relates to an increased risk of coronary atherosclerosis.
BACKGROUND: A prospective follow-up study was conducted to examine the relationship between 9 year change in abdominal obesity and risk of coronary artery calcification (CAC). METHODS: Data on coronary risk factors for 573 postmenopausal women were collected at baseline (1993-1997) and follow-up (2002-2004). At follow-up, the women underwent a multidetector CT to assess coronary calcium using the Agatston score. Markers of abdominal obesity were waist and hip circumference, waist-to-hip ratio (WHR) and body mass index. RESULTS: Compared to subjects whose waist circumference remained below the median at both occasions, those with a waist above the median had a 1.5-fold (95% CI 1.0 to 2.3) increased risk of CAC. Women whose waist rose over the 9 year period had a 2.2-fold (95% CI 1.1 to 4.2) increased risk of CAC, whereas women whose WHR became lower had a non-significant 1.5-fold increased risk of CAC (95% CI 0.7 to 3.0). In contrast, change in body mass index or hip circumference was not related to risk of CAC. CONCLUSION: This study supports the existing evidence that persistent abdominal obesity, as well as an increase in abdominal fat, relates to an increased risk of coronary atherosclerosis.
Authors: Bonnie Spring; Arlen C Moller; Laura A Colangelo; Juned Siddique; Megan Roehrig; Martha L Daviglus; Joseph F Polak; Jared P Reis; Stephen Sidney; Kiang Liu Journal: Circulation Date: 2014-04-28 Impact factor: 29.690
Authors: Jan M Hughes-Austin; Christina L Wassel; Jessica Jiménez; Michael H Criqui; Joachim H Ix; Laura J Rasmussen-Torvik; Matthew J Budoff; Nancy S Jenny; Matthew A Allison Journal: Vasc Med Date: 2014-06-06 Impact factor: 3.239
Authors: Ying-Chao Han; Bin Ma; Song Guo; Mingjie Yang; Li-Jun Li; Shan-Jin Wang; Jun Tan Journal: J Cell Mol Med Date: 2018-01-26 Impact factor: 5.310