OBJECTIVES: To evaluate FCGR3B copy number variation (CNV) in African and European populations and to determine if FCGR3B copy number is associated with SLE and SLE nephritis risk in Afro-Caribbeans, adjusting for African genetic ancestry. METHODS: We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B in relation to SLE and SLE nephritis within a case-control collection of 134 cases of SLE (37 with SLE nephritis) and 589 population controls of mainly Afro-Caribbean descent resident in Trinidad. RESULTS: We found a significant difference in copy number FCGR3B distribution between unadmixed African and European UK cohorts, with 27 (29%) vs 3 (5%) for those with low (0 or 1) copy FCGR3B, respectively, P = 0.002. In a Trinidadian SLE case-control study, low FCGR3B CNV was associated with SLE risk 1.7 (95% CI 1.1, 2.8), P = 0.02, which remained after adjustment for African genetic ancestry; odds ratios (ORs) 1.7 (95% CI 1.0, 2.8), P = 0.04. CONCLUSION: Our studies suggest that FCGR3B low copy number is associated with SLE risk in Afro-Caribbean populations independently of CNV due to African ancestry.
OBJECTIVES: To evaluate FCGR3B copy number variation (CNV) in African and European populations and to determine if FCGR3B copy number is associated with SLE and SLE nephritis risk in Afro-Caribbeans, adjusting for African genetic ancestry. METHODS: We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B in relation to SLE and SLE nephritis within a case-control collection of 134 cases of SLE (37 with SLE nephritis) and 589 population controls of mainly Afro-Caribbean descent resident in Trinidad. RESULTS: We found a significant difference in copy number FCGR3B distribution between unadmixed African and European UK cohorts, with 27 (29%) vs 3 (5%) for those with low (0 or 1) copy FCGR3B, respectively, P = 0.002. In a Trinidadian SLE case-control study, low FCGR3B CNV was associated with SLE risk 1.7 (95% CI 1.1, 2.8), P = 0.02, which remained after adjustment for African genetic ancestry; odds ratios (ORs) 1.7 (95% CI 1.0, 2.8), P = 0.04. CONCLUSION: Our studies suggest that FCGR3B low copy number is associated with SLE risk in Afro-Caribbean populations independently of CNV due to African ancestry.
Authors: Enrique Gonzalez; Hemant Kulkarni; Hector Bolivar; Andrea Mangano; Racquel Sanchez; Gabriel Catano; Robert J Nibbs; Barry I Freedman; Marlon P Quinones; Michael J Bamshad; Krishna K Murthy; Brad H Rovin; William Bradley; Robert A Clark; Stephanie A Anderson; Robert J O'connell; Brian K Agan; Seema S Ahuja; Rosa Bologna; Luisa Sen; Matthew J Dolan; Sunil K Ahuja Journal: Science Date: 2005-01-06 Impact factor: 47.728
Authors: Steven A McCarroll; Alan Huett; Petric Kuballa; Shannon D Chilewski; Aimee Landry; Philippe Goyette; Michael C Zody; Jennifer L Hall; Steven R Brant; Judy H Cho; Richard H Duerr; Mark S Silverberg; Kent D Taylor; John D Rioux; David Altshuler; Mark J Daly; Ramnik J Xavier Journal: Nat Genet Date: 2008-09 Impact factor: 38.330
Authors: Edward J Hollox; Ulrike Huffmeier; Patrick L J M Zeeuwen; Raquel Palla; Jesús Lascorz; Diana Rodijk-Olthuis; Peter C M van de Kerkhof; Heiko Traupe; Gys de Jongh; Martin den Heijer; André Reis; John A L Armour; Joost Schalkwijk Journal: Nat Genet Date: 2007-12-02 Impact factor: 38.330
Authors: Manuela Fanciulli; Penny J Norsworthy; Enrico Petretto; Rong Dong; Lorraine Harper; Lavanya Kamesh; Joanne M Heward; Stephen C L Gough; Adam de Smith; Alexandra I F Blakemore; Philippe Froguel; Catherine J Owen; Simon H S Pearce; Luis Teixeira; Loic Guillevin; Deborah S Cunninghame Graham; Charles D Pusey; H Terence Cook; Timothy J Vyse; Timothy J Aitman Journal: Nat Genet Date: 2007-05-21 Impact factor: 38.330
Authors: Timothy J Aitman; Rong Dong; Timothy J Vyse; Penny J Norsworthy; Michelle D Johnson; Jennifer Smith; Jonathan Mangion; Cheri Roberton-Lowe; Amy J Marshall; Enrico Petretto; Matthew D Hodges; Gurjeet Bhangal; Sheetal G Patel; Kelly Sheehan-Rooney; Mark Duda; Paul R Cook; David J Evans; Jan Domin; Jonathan Flint; Joseph J Boyle; Charles D Pusey; H Terence Cook Journal: Nature Date: 2006-02-16 Impact factor: 49.962
Authors: Young Ho Lee; Sang-Cheol Bae; Young Ho Seo; Jae-Hoon Kim; Sung Jae Choi; Jong Dae Ji; Gwan Gyu Song Journal: Inflamm Res Date: 2015-09-25 Impact factor: 4.575
Authors: Mohammed Uddin; Walter P Maksymowych; Robert Inman; Dafna Gladman; Alexandra Munn; Ramin Yazdani; Fawnda Pellett; Sean Hamilton; Darren D O'Rielly; Proton Rahman Journal: BMC Genet Date: 2013-08-08 Impact factor: 2.797