BACKGROUND: Chronic sinusitis is almost invariably a feature of cystic fibrosis. However, data on the endoscopically confirmed prevalence of chronic polypoid sinusitis (CPS) and its histological features are limited. METHODS: Single centre prospective observational study. Unselected pediatric CF patients (n=81; ≤ 18 years) were endoscopically assessed for the prevalence of CPS. Sixteen of these underwent sinus surgery. The surgically obtained sinus specimens were compared to sinus specimen of non-CF-patients undergoing sinus surgery (n=61), using conventional histology and immunohistochemistry. RESULTS: The prevalence of endoscopically confirmed CPS increased with age from 19% in infants younger than six years reaching 45% in adolescents. In CF patients, histology typically showed dilated glandular ducts and a predominance of mucous glands. The number of plasma cells and mast cells but not of eosinophils was significantly elevated compared to non-CF patients. CONCLUSION: Prevalence of CPS in pediatric CF patients increases with age. Our findings indicate that chronic bacterial infection rather than allergic mechanisms may forward this pathology.
BACKGROUND: Chronic sinusitis is almost invariably a feature of cystic fibrosis. However, data on the endoscopically confirmed prevalence of chronic polypoid sinusitis (CPS) and its histological features are limited. METHODS: Single centre prospective observational study. Unselected pediatric CF patients (n=81; ≤ 18 years) were endoscopically assessed for the prevalence of CPS. Sixteen of these underwent sinus surgery. The surgically obtained sinus specimens were compared to sinus specimen of non-CF-patients undergoing sinus surgery (n=61), using conventional histology and immunohistochemistry. RESULTS: The prevalence of endoscopically confirmed CPS increased with age from 19% in infants younger than six years reaching 45% in adolescents. In CF patients, histology typically showed dilated glandular ducts and a predominance of mucous glands. The number of plasma cells and mast cells but not of eosinophils was significantly elevated compared to non-CF patients. CONCLUSION: Prevalence of CPS in pediatric CF patients increases with age. Our findings indicate that chronic bacterial infection rather than allergic mechanisms may forward this pathology.
Authors: Yanyi Tu; Jing Liu; Tao Li; Xiangmin Zhou; Kai Sen Tan; Hsiao Hui Ong; Kaiyue Sun; Yi Ouyang; Xu Liang; Yew Kwang Ong; Mark Thong; Li Shi; De-Yun Wang Journal: Inflammation Date: 2021-05-17 Impact factor: 4.092
Authors: Julia Hentschel; Manuela Jäger; Natalie Beiersdorf; Nele Fischer; Franziska Doht; Ruth K Michl; Thomas Lehmann; Udo R Markert; Klas Böer; Peter M Keller; Mathias W Pletz; Jochen G Mainz Journal: BMC Pulm Med Date: 2014-05-13 Impact factor: 3.317