| Literature DB >> 21295693 |
Abstract
The nutrient sensor O-GlcNAc transferase modifies proteins with the O-GlcNAc moiety. In this issue, Capotosti et al. (2011) reveal that O-GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it through proteolytic cleavage, providing a surprising link between metabolism and epigenetic regulation of the cell cycle.Entities:
Year: 2011 PMID: 21295693 DOI: 10.1016/j.cell.2011.01.025
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582