Literature DB >> 21295683

Stem cells in brain tumor development.

Sheila R Alcantara Llaguno1, Yuntao Chen, Renée M McKay, Luis F Parada.   

Abstract

Gliomas are highly infiltrative and aggressive brain tumors that are resistant to conventional therapies. Recent studies have implicated neural stem cells (NSCs) in brain tumor initiation and development. Subpopulations of stem-like cancer cells have also been isolated from brain tumors, and are purported to be important mediators of malignant behavior and therapeutic resistance. Similar signaling pathways may be operative in both neural and cancer stem cells, suggesting that neural developmental systems may provide important clues on brain tumorigenesis. Transcriptional regulators such as microRNAs may also contribute to NSC and brain tumor development. Understanding the biology of neural and cancer stem cells and their regulatory mechanisms may directly impact current efforts for more directed therapeutics against these highly aggressive tumors.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21295683     DOI： 10.1016/B978-0-12-380916-2.00002-4

Source DB:  PubMed          Journal:  Curr Top Dev Biol        ISSN： 0070-2153            Impact factor:   4.897


  6 in total

1.  The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas.

Authors:  Elena Binda; Alberto Visioli; Fabrizio Giani; Giuseppe Lamorte; Massimiliano Copetti; Ken L Pitter; Jason T Huse; Laura Cajola; Nadia Zanetti; Francesco DiMeco; Lidia De Filippis; Annunziato Mangiola; Giulio Maira; Carmelo Anile; Pasquale De Bonis; Brent A Reynolds; Elena B Pasquale; Angelo L Vescovi
Journal:  Cancer Cell       Date:  2012-12-11       Impact factor: 31.743

Review 2.  The roles of hypoxia-inducible factors in regulating neural stem cells migration to glioma stem cells and determinating their fates.

Authors:  Suojun Zhang; Xiao Luo; Feng Wan; Ting Lei
Journal:  Neurochem Res       Date:  2012-09-19       Impact factor: 3.996

3.  RalA is overactivated in medulloblastoma.

Authors:  Kevin F Ginn; Ben Fangman; Kaoru Terai; Amanda Wise; Daniel Ziazadeh; Kushal Shah; Robyn Gartrell; Brandon Ricke; Kyle Kimura; Sharad Mathur; Emma Borrego-Diaz; Faris Farassati
Journal:  J Neurooncol       Date:  2016-08-26       Impact factor: 4.130

Review 4.  Bad wrap: Myelin and myelin plasticity in health and disease.

Authors:  Erin M Gibson; Anna C Geraghty; Michelle Monje
Journal:  Dev Neurobiol       Date:  2017-10-17       Impact factor: 3.964

5.  Growth factor independence underpins a paroxysmal, aggressive Wnt5aHigh/EphA2Low phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy.

Authors:  Nadia Trivieri; Alberto Visioli; Gandino Mencarelli; Maria Grazia Cariglia; Laura Marongiu; Riccardo Pracella; Fabrizio Giani; Amata Amy Soriano; Chiara Barile; Laura Cajola; Massimiliano Copetti; Orazio Palumbo; Federico Legnani; Francesco DiMeco; Leonardo Gorgoglione; Angelo L Vescovi; Elena Binda
Journal:  J Exp Clin Cancer Res       Date:  2022-04-12

6.  NOX4 regulates TGFβ-induced proliferation and self-renewal in glioblastoma stem cells.

Authors:  Pedro García-Gómez; Irene Golán; Mahsa S Dadras; Artur Mezheyeuski; Claudia Bellomo; Kalliopi Tzavlaki; Anita Morén; Jordi Carreras-Puigvert; Laia Caja
Journal:  Mol Oncol       Date:  2022-03-14       Impact factor: 7.449
  6 in total

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