| Literature DB >> 21295525 |
Kuo-Tai Hua1, Ching-Ting Tan, Gunnar Johansson, Jang-Ming Lee, Pei-Wen Yang, Hsin-Yi Lu, Chi-Kuan Chen, Jen-Liang Su, Poshen B Chen, Yu-Ling Wu, Chia-Chun Chi, Hsin-Jung Kao, Hou-Jung Shih, Min-Wei Chen, Ming-Hsien Chien, Pai-Sheng Chen, Wei-Jiunn Lee, Tsu-Yao Cheng, George Rosenberger, Chee-Yin Chai, Chih-Jen Yang, Ming-Shyan Huang, Tsung-Ching Lai, Teh-Ying Chou, Michael Hsiao, Min-Liang Kuo.
Abstract
N-α-acetyltransferase 10 protein, Naa10p, is an N-acetyltransferase known to be involved in cell cycle control. We found that Naa10p was expressed lower in varieties of malignancies with lymph node metastasis compared with non-lymph node metastasis. Higher Naa10p expression correlates the survival of lung cancer patients. Naa10p significantly suppressed migration, tumor growth, and metastasis independent of its enzymatic activity. Instead, Naa10p binds to the GIT-binding domain of PIX, thereby preventing the formation of the GIT-PIX-Paxillin complex, resulting in reduced intrinsic Cdc42/Rac1 activity and decreased cell migration. Forced expression of PIX in Naa10-transfected tumor cells restored the migration and metastasis ability. We suggest that Naa10p functions as a tumor metastasis suppressor by disrupting the migratory complex, PIX-GIT- Paxillin, in cancer cells.Entities:
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Year: 2011 PMID： 21295525 DOI： 10.1016/j.ccr.2010.11.010
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743