| Literature DB >> 21295347 |
Jonathan Satin1, Elizabeth A Schroder, Shawn M Crump.
Abstract
L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The classical LTCC function is to mediate trans-sarcolemmal Ca(2+) flux. This review focuses on the contribution of a mobile segment of the LTCC that regulates ion channel function, and also serves as a regulator of transcription in the nucleus. Specifically we highlight recent work demonstrating an auto-feedback regulatory pathway whereby the LTCC transcription factor regulates the LTCC. Also discussed is acute and long-term regulation of function by the LTCC-transcription regulator. 2011 Elsevier Ltd. All rights reserved.Entities:
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Year: 2011 PMID: 21295347 PMCID: PMC3097264 DOI: 10.1016/j.ceca.2011.01.001
Source DB: PubMed Journal: Cell Calcium ISSN: 0143-4160 Impact factor: 6.817