Secondary metabolites from the leaves of Neolitsea hiiranensis and the anti-inflammatory activity of some of them.

Seven sesquiterpenoids, hiiranlactones A-D (1-4), (-)-ent-6α-methoxyeudesm-4(15)-en-1β-ol (5), (+)-villosine (6), hiiranepoxide (7), and one triterpenoid, hiiranterpenone (8), together with 22 known compounds, were isolated from the leaves of Neolitsea hiiranensis (Lauraceae). Their structures were elucidated by spectroscopic analysis and single crystal X-ray diffraction. Among the isolates, hiiranlactone B (2) and hiiranlactone D (4) exhibited inhibitory activity against fMLP-induced superoxide production by human neutrophils with IC(50) values of 21.86±3.97 and 25.78±4.77μM, respectively.