Literature DB >> 21295269

An electrifying iPSC disease model: long QT syndrome type 2 and heart cells in a dish.

Timothy J Kamp1.   

Abstract

In a recent Nature paper, Itzhaki et al. (2011) generate induced pluripotent stem cells (iPSCs) from patients with a potentially fatal inherited arrhythmia, long QT syndrome type 2. Cardiomyocytes differentiated from the patient-derived iPSCs exhibit the hallmark cardiac electrical signatures of the disease, which can be reversed by pharmacological intervention.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21295269     DOI： 10.1016/j.stem.2011.01.010

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  6 in total

Review 1.  Human pluripotent stem cell-derived cardiomyocytes for heart regeneration, drug discovery and disease modeling: from the genetic, epigenetic, and tissue modeling perspectives.

Authors:  Maggie Chow; Kenneth R Boheler; Ronald A Li
Journal:  Stem Cell Res Ther       Date:  2013-08-14       Impact factor: 6.832

Review 2.  Channelopathies from mutations in the cardiac sodium channel protein complex.

Authors:  Graham S Adsit; Ravi Vaidyanathan; Carla M Galler; John W Kyle; Jonathan C Makielski
Journal:  J Mol Cell Cardiol       Date:  2013-04-01       Impact factor: 5.000

3.  In vitro model of ischemic heart failure using human induced pluripotent stem cell-derived cardiomyocytes.

Authors:  Justin Davis; Ahmad Chouman; Jeffery Creech; Andre Monteiro da Rocha; Daniela Ponce-Balbuena; Eric N Jimenez Vazquez; Ruthann Nichols; Andrey Lozhkin; Nageswara R Madamanchi; Katherine F Campbell; Todd J Herron
Journal:  JCI Insight       Date:  2021-05-24

4.  Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.

Authors:  Cecile Terrenoire; Kai Wang; Kelvin W Chan Tung; Wendy K Chung; Robert H Pass; Jonathan T Lu; Jyh-Chang Jean; Amel Omari; Kevin J Sampson; Darrell N Kotton; Gordon Keller; Robert S Kass
Journal:  J Gen Physiol       Date:  2013-01       Impact factor: 4.086

Review 5.  The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside.

Authors:  Nina Xie; Beisha Tang
Journal:  Stem Cells Int       Date:  2016-01-06       Impact factor: 5.443

Review 6.  Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies.

Authors:  Karina O Brandão; Viola A Tabel; Douwe E Atsma; Christine L Mummery; Richard P Davis
Journal:  Dis Model Mech       Date:  2017-09-01       Impact factor: 5.758
  6 in total

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