BACKGROUND AND PURPOSE: Despite the improving imaging techniques, it remains challenging to predict the outcome early after transient cerebral ischemia. The aim of this study was thus to identify early metabolic biomarkers for outcome prediction. METHODS: We modeled transient ischemic attacks and strokes in mice. Using high-field MR spectroscopy, we correlated early changes in the neurochemical profile of the ischemic striatum with histopathologic alterations at a later time point. RESULTS: A significant increase in glutamine was measured between 3 hours and 8 hours after all ischemic events followed by reperfusion independently of the outcome and can thus be considered as an indicator of recent transient ischemia. On the other hand, a reduction of the score obtained by summing the concentrations of N-acetyl aspartate, glutamate, and taurine was a good predictor of an irreversible lesion as early as 3 hours after ischemia. CONCLUSIONS: We identified biomarkers of reversible and irreversible ischemic damage, which can be used in an early predictive evaluation of stroke outcome.
BACKGROUND AND PURPOSE: Despite the improving imaging techniques, it remains challenging to predict the outcome early after transient cerebral ischemia. The aim of this study was thus to identify early metabolic biomarkers for outcome prediction. METHODS: We modeled transient ischemic attacks and strokes in mice. Using high-field MR spectroscopy, we correlated early changes in the neurochemical profile of the ischemic striatum with histopathologic alterations at a later time point. RESULTS: A significant increase in glutamine was measured between 3 hours and 8 hours after all ischemic events followed by reperfusion independently of the outcome and can thus be considered as an indicator of recent transient ischemia. On the other hand, a reduction of the score obtained by summing the concentrations of N-acetyl aspartate, glutamate, and taurine was a good predictor of an irreversible lesion as early as 3 hours after ischemia. CONCLUSIONS: We identified biomarkers of reversible and irreversible ischemic damage, which can be used in an early predictive evaluation of stroke outcome.
Authors: Elena Jiménez-Xarrié; Myriam Davila; Sara Gil-Perotín; Andrés Jurado-Rodríguez; Ana Paula Candiota; Raquel Delgado-Mederos; Silvia Lope-Piedrafita; José Manuel García-Verdugo; Carles Arús; Joan Martí-Fàbregas Journal: J Cereb Blood Flow Metab Date: 2015-01-21 Impact factor: 6.200
Authors: Hamid Moha Ou Maati; Catherine Widmann; Djamila Sedjelmaci; Djamila Sedjelmaci Bernard Gallois; Bernard Gallois; Djamila Sedjelmaci Bernard Gallois; Catherine Heurteaux; Marc Borsotto; Michel Hugues Journal: PLoS One Date: 2013-07-02 Impact factor: 3.240