BACKGROUND: Psoriasis is a common chronic immune-mediated inflammatory disorder of the skin with several associated comorbidities. OBJECTIVE: To assess the prevalence of comorbidities in a cohort of psoriasis patients within the Canadian province of Newfoundland and Labrador (NL). METHODS: This cross-sectional observational study investigated hospital-coded comorbidities associated with psoriasis in comparison to the general NL hospitalized population. RESULTS: Patients died significantly younger than the general population, with patients having an earlier disease onset (≤ 25 years) dying at a younger age than those with a later onset (> 25 years; 59.3 vs 71.2; p = .001). Patients were hospitalized more frequently for several system disorders than the general population, and a potential association was observed between prognostic factors such as age at onset, disease severity, and HLA-Cw6 genotype and certain comorbid conditions. CONCLUSION: This study supports an association between psoriasis and other conditions, such as circulatory and endocrine diseases.
BACKGROUND:Psoriasis is a common chronic immune-mediated inflammatory disorder of the skin with several associated comorbidities. OBJECTIVE: To assess the prevalence of comorbidities in a cohort of psoriasispatients within the Canadian province of Newfoundland and Labrador (NL). METHODS: This cross-sectional observational study investigated hospital-coded comorbidities associated with psoriasis in comparison to the general NL hospitalized population. RESULTS:Patients died significantly younger than the general population, with patients having an earlier disease onset (≤ 25 years) dying at a younger age than those with a later onset (> 25 years; 59.3 vs 71.2; p = .001). Patients were hospitalized more frequently for several system disorders than the general population, and a potential association was observed between prognostic factors such as age at onset, disease severity, and HLA-Cw6 genotype and certain comorbid conditions. CONCLUSION: This study supports an association between psoriasis and other conditions, such as circulatory and endocrine diseases.
Authors: A B Kimball; C Leonardi; M Stahle; W Gulliver; M Chevrier; S Fakharzadeh; K Goyal; S Calabro; W Langholff; A Menter Journal: Br J Dermatol Date: 2014-07-16 Impact factor: 9.302
Authors: Ole Ahlehoff; Jesper Lindhardsen; Gunnar H Gislason; Jonas B Olesen; Mette Charlot; Lone Skov; Christian Torp-Pedersen; Peter R Hansen Journal: BMC Cardiovasc Disord Date: 2012-09-24 Impact factor: 2.298