David Drake1, Alissa L Villhauer. 1. Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA, USA. david-drake@uiowa.edu
Abstract
OBJECTIVE: The study was conducted to determine the bactericidal activity of a stabilized chlorine dioxide oral rinse (ClōSYS Oral Rinse) compared to products currently available on the market. METHODS: Oral bacteria associated with gingivitis and periodontitis were exposed to rinses for one minute and five minutes. The numbers of colony forming units per milliliter (CFU/ml) were measured prior to and following exposure to determine the bactericidal activity. RESULTS: As expected, Listerine and Crest Pro-Health demonstrated complete kill on all bacteria exposed within one minute. Breath Rx exhibited the weakest levels of bactericidal effects overall. ClōSYS and chlorhexidine rinses proved identical 100% kills against the periodontal pathogens at five minutes; in some cases, ClōSYS oral rinse achieved a higher kill at the one-minute mark over the chlorhexidine rinse. CONCLUSION: The results demonstrated that ClōSYS Oral Rinse has potential for providing a therapeutic benefit, making it an attractive option to induce compliance in patients concerned about taste and tooth discoloration during oral health therapy.
OBJECTIVE: The study was conducted to determine the bactericidal activity of a stabilized chlorine dioxide oral rinse (ClōSYS Oral Rinse) compared to products currently available on the market. METHODS: Oral bacteria associated with gingivitis and periodontitis were exposed to rinses for one minute and five minutes. The numbers of colony forming units per milliliter (CFU/ml) were measured prior to and following exposure to determine the bactericidal activity. RESULTS: As expected, Listerine and Crest Pro-Health demonstrated complete kill on all bacteria exposed within one minute. Breath Rx exhibited the weakest levels of bactericidal effects overall. ClōSYS and chlorhexidine rinses proved identical 100% kills against the periodontal pathogens at five minutes; in some cases, ClōSYS oral rinse achieved a higher kill at the one-minute mark over the chlorhexidine rinse. CONCLUSION: The results demonstrated that ClōSYS Oral Rinse has potential for providing a therapeutic benefit, making it an attractive option to induce compliance in patients concerned about taste and tooth discoloration during oral health therapy.
Authors: Briana Joy Travis; James Elste; Feng Gao; Bo Young Joo; Maria Cuevas-Nunez; Ellen Kohlmeir; Vaibhav Tiwari; John C Mitchell Journal: Oral Dis Date: 2022-07-16 Impact factor: 4.068