Literature DB >> 21290070

Copper(II) enhances membrane-bound α-synuclein helix formation.

Heather R Lucas1, Jennifer C Lee.   

Abstract

Interactions of copper and membranes with α-synuclein have been implicated in pathogenic mechanisms of Parkinson's disease, yet work examining both concurrently is scarce. We have examined the effect of copper(ii) on protein/vesicle binding and found that both the copper(ii) affinity and α-helical content are enhanced for the membrane-bound protein.

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Year:  2011        PMID： 21290070      PMCID： PMC3196632          DOI： 10.1039/c0mt00088d

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  38 in total

Review 1.  Metalloproteomics and metal toxicology of α-synuclein.

Authors:  Aaron Santner; Vladimir N Uversky
Journal:  Metallomics       Date:  2010-05-13       Impact factor: 4.526

2.  Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy.

Authors:  Christina R Bodner; Christopher M Dobson; Ad Bax
Journal:  J Mol Biol       Date:  2009-05-27       Impact factor: 5.469

3.  Residual structure and dynamics in Parkinson's disease-associated mutants of alpha-synuclein.

Authors:  R Bussell; D Eliezer
Journal:  J Biol Chem       Date:  2001-10-04       Impact factor: 5.157

4.  Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein.

Authors:  Andrés Binolfi; Esaú E Rodriguez; Daniela Valensin; Nicola D'Amelio; Emiliano Ippoliti; Gonzalo Obal; Rosario Duran; Alessandra Magistrato; Otto Pritsch; Markus Zweckstetter; Gianni Valensin; Paolo Carloni; Liliana Quintanar; Christian Griesinger; Claudio O Fernández
Journal:  Inorg Chem       Date:  2010-10-22       Impact factor: 5.165

5.  Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

Authors:  Michael J Volles; Peter T Lansbury
Journal:  Biochemistry       Date:  2002-04-09       Impact factor: 3.162

6.  Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form.

Authors:  He-Jin Lee; Chan Choi; Seung-Jae Lee
Journal:  J Biol Chem       Date:  2001-10-25       Impact factor: 5.157

7.  Identification of the minimal copper(II)-binding alpha-synuclein sequence.

Authors:  Mark S Jackson; Jennifer C Lee
Journal:  Inorg Chem       Date:  2009-10-05       Impact factor: 5.165

8.  Cerebral bioimaging of Cu, Fe, Zn, and Mn in the MPTP mouse model of Parkinson's disease using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).

Authors:  Andreas Matusch; Candan Depboylu; Christoph Palm; Bei Wu; Günter U Höglinger; Martin K-H Schäfer; J Sabine Becker
Journal:  J Am Soc Mass Spectrom       Date:  2009-10-06       Impact factor: 3.109

9.  Unique copper-induced oligomers mediate alpha-synuclein toxicity.

Authors:  Josephine A Wright; Xiaoyan Wang; David R Brown
Journal:  FASEB J       Date:  2009-03-26       Impact factor: 5.191

10.  Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.

Authors:  Jacqueline Burré; Manu Sharma; Theodoros Tsetsenis; Vladimir Buchman; Mark R Etherton; Thomas C Südhof
Journal:  Science       Date:  2010-08-26       Impact factor: 47.728
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  9 in total

Review 1.  Coherent and Contradictory Facts, Feats and Fictions Associated with Metal Accumulation in Parkinson's Disease: Epicenter or Outcome, Yet a Demigod Question.

Authors:  Mohd Sami Ur Rasheed; Sonam Tripathi; Saumya Mishra; Mahendra Pratap Singh
Journal:  Mol Neurobiol       Date:  2016-08-01       Impact factor: 5.590

2.  Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast.

Authors:  Xianpeng Liu; Yong Joo Lee; Liang-Chun Liou; Qun Ren; Zhaojie Zhang; Shaoxiao Wang; Stephan N Witt
Journal:  Hum Mol Genet       Date:  2011-06-03       Impact factor: 6.150

3.  Stability of HA2 Prefusion Structure and pH-Induced Conformational Changes in the HA2 Domain of H3N2 Hemagglutinin.

Authors:  Micah W Eller; Hew Ming Helen Siaw; R Brian Dyer
Journal:  Biochemistry       Date:  2021-08-26       Impact factor: 3.162

4.  Coordination of copper to the membrane-bound form of α-synuclein.

Authors:  Christopher G Dudzik; Eric D Walter; Benjamin S Abrams; Melissa S Jurica; Glenn L Millhauser
Journal:  Biochemistry       Date:  2012-12-26       Impact factor: 3.162

5.  Conversion of natively unstructured α-synuclein to its α-helical conformation significantly attenuates production of reactive oxygen species.

Authors:  Binbin Zhou; Yuanqiang Hao; Chengshan Wang; Ding Li; You-Nian Liu; Feimeng Zhou
Journal:  J Inorg Biochem       Date:  2012-09-08       Impact factor: 4.155

Review 6.  Iron Redox Chemistry and Implications in the Parkinson's Disease Brain.

Authors:  Dinendra L Abeyawardhane; Heather R Lucas
Journal:  Oxid Med Cell Longev       Date:  2019-10-09       Impact factor: 6.543

Review 7.  Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation.

Authors:  Heather R Lucas; Ricardo D Fernández
Journal:  Neural Regen Res       Date:  2020-03       Impact factor: 5.135

8.  Copper Dependent Modulation of α-Synuclein Phosphorylation in Differentiated SHSY5Y Neuroblastoma Cells.

Authors:  Marco Greco; Chiara Carmela Spinelli; Lidia De Riccardis; Alessandro Buccolieri; Simona Di Giulio; Debora Musarò; Claudia Pagano; Daniela Manno; Michele Maffia
Journal:  Int J Mol Sci       Date:  2021-02-18       Impact factor: 5.923

Review 9.  Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson's Disease.

Authors:  Juan Antonio Castillo-Gonzalez; Maria De Jesus Loera-Arias; Odila Saucedo-Cardenas; Roberto Montes-de-Oca-Luna; Aracely Garcia-Garcia; Humberto Rodriguez-Rocha
Journal:  Parkinsons Dis       Date:  2017-11-23
  9 in total

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