[Animal models for bone and joint disease. Mouse models develop spontaneous osteoarthritis].

Osteoarthritis (OA) is a major joint disorder that significantly decreases the quality of life of elderly. Animal models, especially mice, have contributed in studies on a number of diseases. Among mice develop OA spontaneously, genetically-modified and naturally mutated mice have been reported. STR/ort is a well recognized model, which pronounces natural onset OA. Here we introduce the several models possessed spontaneous OA with focusing the feature and utilization of STR/ort.