Jenny Brändstedt1, Björn Nodin, Jonas Manjer, Karin Jirström. 1. Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden. jenny.brandstedt@med.lu.se
Abstract
OBJECTIVE: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study. METHODS: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. RESULTS: A high WHR (<0.77, ≥0.77 to <0.81, ≥0.81cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36-1.00; p-trend=0.04), particularly tumours of differentiation grades 1 and 2 (RR 0.27; 0.09-0.81; p-trend=0.03) and clinical stages 1 and 2 (RR 0.32; 0.10-0.97; p-trend=0.03) and these associations were stronger in postmenopausal women. Neither height, weight, BMI, body fat percentage, waist- or hip circumference were associated with overall risk, nor with risk for different subtypes, differentiation grade or stage. CONCLUSIONS: These results demonstrate that a high WHR is associated with a decreased risk of EOC. Other anthropometric factors were not associated with EOC risk.
OBJECTIVE: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malmö Diet and Cancer Study. METHODS: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. RESULTS: A high WHR (<0.77, ≥0.77 to <0.81, ≥0.81cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36-1.00; p-trend=0.04), particularly tumours of differentiation grades 1 and 2 (RR 0.27; 0.09-0.81; p-trend=0.03) and clinical stages 1 and 2 (RR 0.32; 0.10-0.97; p-trend=0.03) and these associations were stronger in postmenopausal women. Neither height, weight, BMI, body fat percentage, waist- or hip circumference were associated with overall risk, nor with risk for different subtypes, differentiation grade or stage. CONCLUSIONS: These results demonstrate that a high WHR is associated with a decreased risk of EOC. Other anthropometric factors were not associated with EOC risk.
Authors: Jennifer Ose; Helena Schock; Anne Tjønneland; Louise Hansen; Kim Overvad; Laure Dossus; Françoise Clavel-Chapelon; Laura Baglietto; Heiner Boeing; Antonia Trichopolou; Vassiliki Benetou; Pagona Lagiou; Giovanna Masala; Giovanna Tagliabue; Rosario Tumino; Carlotta Sacerdote; Amalia Mattiello; H B As Bueno-de-Mesquita; Petra H M Peeters; N Charlotte Onland-Moret; Elisabete Weiderpass; Inger T Gram; Soledad Sánchez; Mireia Obon-Santacana; Maria-José Sànchez-Pérez; Nerea Larrañaga; José María Huerta Castaño; Eva Ardanaz; Jenny Brändstedt; Eva Lundin; Annika Idahl; Ruth C Travis; Kay-Tee Khaw; Sabina Rinaldi; Isabelle Romieu; Melissa A Merritt; Marc J Gunter; Elio Riboli; Rudolf Kaaks; Renée T Fortner Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-04-08 Impact factor: 4.254
Authors: Hanna Sartor; Maria Bjurberg; Mihaela Asp; Anna Kahn; Jenny Brändstedt; Päivi Kannisto; Karin Jirström Journal: J Ovarian Res Date: 2020-03-07 Impact factor: 4.234